Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
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DOI：
10.1016/j.cmet.2017.09.008
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发表时间：
2017-10-03
期刊：
影响因子：
29
通讯作者：
Nieuwdorp, Max
中科院分区：
文献类型：
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作者：
Kootte, Ruud S.;Levin, Evgeni;Nieuwdorp, Max
肠道微生物群与胰岛素抵抗有关，尽管关于人类因果关系的证据很少。因此，我们研究了瘦供体（同种异体）与自身（自体）粪便微生物群移植（FMT）对男性代谢综合征受体的影响。尽管我们在FMT后18周没有观察到代谢变化，但同种异体FMT后6周的胰岛素敏感性显着改善，并伴有微生物群组成的改变。我们还观察到血浆代谢物如γ -氨基丁酸的变化，并表明同种异体FMT后的代谢反应（定义为FMT后6周胰岛素敏感性的改善）依赖于基线时粪便微生物多样性的减少。综上所述，精瘦供体FMT对葡萄糖代谢的有益影响与肠道微生物群和血浆代谢产物的变化有关，可以根据粪便微生物群的基线组成来预测。
The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as gamma-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.