Evidence for widespread infection of hepatitis E virus among wild rats in Japan
Evidence for widespread infection of hepatitis E virus among wild rats in Japan
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DOI：
10.1016/s1386-6346(03)00192-x
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发表时间：
2003-09-01
影响因子：
4.2
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Hirano, M;Ding, X;Abe, K
包括日本在内的工业化国家报告了零星的戊型肝炎病例。这些患者中戊型肝炎病毒(HEV)的来源尚不清楚，尽管已有人畜共患传播的说法。为了研究啮齿动物是否可能是HEV的宿主，我们利用日本野生啮齿动物的血清样本进行了HEV重组衣壳蛋白抗体的流行病学调查。114只挪威鼠(31.5%)和12只黑鼠(13.3%)抗-HEVIg G阳性。相反，55只小鼠的血清抗-HEV-Ig G均为阴性。挪威大鼠的抗体阳性率随体重增加而增加。在本次调查的所有五个地区都发现了阳性鼠，但不同地区野生鼠中抗-HEV-Ig G的流行率不同。尽管日本是戊型肝炎的非流行国家，但在日本的野鼠中观察到了广泛的HEV感染。我们的结果表明，HEV或一种密切相关的病毒在日本野鼠中传播。(C)2003 Elsevier Science B.V.保留所有权利。
Sporadic cases of hepatitis E have been reported in industrialized countries, including Japan. The source of hepatitis E virus (HEV) in these patients is unknown, although zoonotic transmission has been suggested. To investigate whether or not rodents might be a reservoir of HEV, we conducted an epidemiological survey for the antibody to a recombinant capsid protein of HEV using serum samples from wild rodents in Japan. One hundred and fourteen of 362 (31.5%) Norway rats (Rattus norvegicus) and 12 of 90 (13.3%) black rats (Rattus rattus) were positive for anti-HEV IgG. In contrast, all of the sera from 55 mice were negative for anti-HEV IgG. The rate of antibody positivity increased with weight among Norway rats. Seropositive rats were found in all five districts surveyed in this study, but the prevalence of anti-HEV IgG in wild rats differed among these prefectures. Despite the fact that Japan is a non-endemic country of hepatitis E, widespread infection of HEV was observed among wild rats in Japan. Our results suggested that HEV or a closely related virus is circulating among wild rats in Japan. (C) 2003 Elsevier Science B.V. All rights reserved.