Asymmetric addition of an N-methyl C(sp3)-H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst
Asymmetric addition of an N-methyl C(sp3)-H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst
复制标题
DOI：
10.1039/d2cc04642c
复制
发表时间：
2022-09-22
影响因子：
4.9
通讯作者：
Nishimura，Takahiro
中科院分区：
文献类型：
--
作者：
Sakamoto，Kana;Nishimura，Takahiro
以膦-烯烃配体为催化剂，实现了3-三氟甲基-2-(N-甲氨基)吡啶上N-甲基与环烯的不对称C-H加成反应。吲哚及其7-取代的衍生物、榄香烯和一些双环烯进行了加成反应，得到了产率高、对映体选择性高的相应产品。
Iridium-catalyzed asymmetric C–H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine–olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give the corresponding products in good yields with high enantioselectivity.