Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum.
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum.
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DOI：
10.1111/imm.13483
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发表时间：
2022-08
期刊：
影响因子：
6.4
通讯作者：
Jenkins SJ
中科院分区：
文献类型：
--
作者：
Louwe PA;Forbes SJ;Bénézech C;Pridans C;Jenkins SJ
腹膜巨噬细胞与邻近大网膜之间的关系尚不清楚。在这里，我们描述了两类以CD102表达为特征的大网膜巨噬细胞，并使用过继细胞转移方法来研究这些细胞是否起源于腹膜巨噬细胞，以及这是否取决于炎症状态、腹膜巨噬细胞的来源和大网膜壁龛的可用性。我们发现，虽然已建立的常驻腹膜巨噬细胞大多不能迁移到大网膜，但在腹膜炎症消退后的几个月里，单核细胞来源的常驻细胞很容易迁移并形成大网膜CD102+巨噬细胞的重要组成部分。相反，在没有内源性腹膜巨噬细胞和大网膜巨噬细胞的情况下，这两个群体都有向大网膜迁移的能力。然而，炎性巨噬细胞更有效地扩张和更有效地重新填充CD102+和CD102CD102−群体，而已建立的常驻巨噬细胞通过招募单核细胞部分地重建了大网膜生态位。因此，细胞来源决定了腹膜巨噬细胞向大网膜的迁移，并使已建立的常驻巨噬细胞能够驱动单核细胞来源的细胞的渗透。
The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer approach to investigate whether these arise from peritoneal macrophages, and whether this depends upon inflammatory status, the origin of peritoneal macrophages and availability of the omental niches. We show that whereas established resident peritoneal macrophages largely fail to migrate to the omentum, monocyte-derived resident cells readily migrate and form a substantial component of omental CD102+ macrophages in the months following resolution of peritoneal inflammation. In contrast, both populations had the capacity to migrate to the omentum in the absence of endogenous peritoneal and omental macrophages. However, inflammatory macrophages expanded more effectively and more efficiently repopulated both CD102+ and CD102− omental populations, whereas established resident macrophages partially reconstituted the omental niche via recruitment of monocytes. Hence, cell origin determines the migration of peritoneal macrophages to the omentum and predisposes established resident macrophages to drive infiltration of monocyte-derived cells.
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影响因子：
20.3
作者：
Gautier, Emmanuel L.;Ivanov, Stoyan;Randolph, Gwendalyn J.
通讯作者：
Randolph, Gwendalyn J.
影响因子：
30.5
作者：
Aegerter, Helena;Kulikauskaite, Justina;Wack, Andreas
通讯作者：
Wack, Andreas
影响因子：
32.4
作者：
Buechler, Matthew B.;Kim, Ki-Wook;Turley, Shannon J.
通讯作者：
Turley, Shannon J.
影响因子：
32.4
作者：
Jackson-Jones, Lucy Helen;Smith, Peter;Benezech, Cecile
通讯作者：
Benezech, Cecile
DOI：
10.1038/mt.2014.112
发表时间：
2014-09
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Gow DJ;Sauter KA;Pridans C;Moffat L;Sehgal A;Stutchfield BM;Raza S;Beard PM;Tsai YT;Bainbridge G;Boner PL;Fici G;Garcia-Tapia D;Martin RA;Oliphant T;Shelly JA;Tiwari R;Wilson TL;Smith LB;Mabbott NA;Hume DA
通讯作者：
Hume DA