Prospective study of recreational physical activity and ovarian cancer
Prospective study of recreational physical activity and ovarian cancer
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DOI：
10.1093/jnci/93.12.942
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发表时间：
2001-06-20
期刊：
影响因子：
--
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
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作者：
Bertone, ER;Willett, WC;Hankinson, SE
背景资料：据推测，体育活动可以通过降低雌激素水平，减少体脂和减少排卵频率来降低卵巢癌的风险。对这种关系的流行病学研究得到了不一致的结果。迄今为止唯一的前瞻性研究报告了频繁的剧烈运动和卵巢癌风险之间的正相关。我们在护士健康研究队列中进一步评估了这种关系。研究方法：在1980年，1982年，1986年，1988年，1992年和1994年，通过问卷调查评估参与娱乐性体育活动，问题评估运动频率，持续时间和强度。结果调整了年龄，产次，口服避孕药的使用，输卵管结扎，和其他卵巢癌的危险因素。所有统计检验均为双侧检验。结果如下：在16年的随访期间（1980年至1996年），92825名队列成员累积了120万人年，确诊了377例上皮性卵巢癌病例。每周从事娱乐性体力活动7小时或以上的女性与每周少于1小时的女性相比，卵巢癌的相对风险（RR）为0.80（95%置信区间[CI] = 0.49至1.32; P趋势= 0.59）。当考虑到活动的频率和强度时，活动水平也与卵巢癌风险降低无关。与不活动的女性相比，报告代谢当量工作时间（MET小时）高活动的参与者患卵巢癌的风险更高（RR为20至25）。
Background: It has been hypothesized that physical activity may reduce the risk of ovarian cancer by decreasing estrogen levels, reducing body fat, and reducing the frequency of ovulation. Epidemiologic studies of this relationship have obtained inconsistent results. The only prospective study to date reported a positive association between frequent vigorous exercise and ovarian cancer risk. We further evaluated this relationship in the Nurses' Health Study cohort. Methods: Participation in recreational physical activity was assessed by questionnaire in 1980, 1982, 1986, 1988, 1992, and 1994, with questions assessing exercise frequency, duration, and intensity. Results were adjusted for age, parity, oral contraceptive use, tubal ligation, and other risk factors for ovarian cancer. All statistical tests were two-sided. Results: During a 16-year follow-up (from 1980 to 1996), 1.2 million person-years were accrued by 92 825 cohort members, and 377 cases of epithelial ovarian cancer were confirmed. The relative risk (RR) of ovarian cancer for women engaging in recreational physical activity for 7 hours or more per week compared with those reporting less than 1 hour per week was 0.80 (95% confidence interval [CI] = 0.49 to 1.32; P-trend =.59). When both the frequency and intensity of activity were taken into account, activity level was also not associated with a reduced risk of ovarian cancer. Compared with inactive women, participants reporting high activity in terms of metabolic equivalent task hours (MET hours) were at greater risk of ovarian cancer (RR for 20 to