Mammalian nicotinic acetylcholine receptors: from structure to function.
Mammalian nicotinic acetylcholine receptors: from structure to function.
复制标题
哺乳动物烟碱乙酰胆碱受体：从结构到功能。
DOI：
10.1152/physrev.00015.2008
复制
发表时间：
2009-01
影响因子：
33.6
通讯作者：
Rogers SW
中科院分区：
文献类型：
--
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
世纪之交，兰利对尼古丁的经典研究引入了“接受物质”的概念，“受体”的概念由此浮出水面。随后的研究在电鳐电器官（肌肉型烟碱受体（nAChR）的丰富来源）和α-银环蛇毒素（一种与肌肉nAChR假不可逆结合的蛇毒素）的发现的帮助下，导致肌肉nAChR成为迄今为止最具特征的配体门控离子通道。随着20世纪80年代后期功能和遗传研究的进展，证实了哺乳动物大脑中存在nAChR，并且认识到许多nAChR亚型有助于尼古丁和其他滥用药物的精神活性特性以及各种疾病的神经病理学，包括阿尔茨海默氏症，帕金森氏症和精神分裂症，已经出现。这篇综述提供了一个全面的概述，这些研究结果和最近的启示的影响，丰富的多样性的功能和表达的受体家族对整个身体的神经元和非神经元细胞。尽管有这些众多的发展，我们的理解的贡献特定的神经元nAChR亚型的生理学的许多方面在整个身体仍然处于起步阶段。
The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a “receptive substance,” from which the idea of a “receptor” came to light. Subsequent studies aided by the Torpedo electric organ, a rich source of muscle-type nicotinic receptors (nAChRs), and the discovery of α-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the muscle nAChR, resulted in the muscle nAChR being the best characterized ligand-gated ion channel hitherto. With the advancement of functional and genetic studies in the late 1980s, the existence of nAChRs in the mammalian brain was confirmed and the realization that the numerous nAChR subtypes contribute to the psychoactive properties of nicotine and other drugs of abuse and to the neuropathology of various diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, has since emerged. This review provides a comprehensive overview of these findings and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body. Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy.
登录
查看更多内容
影响因子：
5
作者：
Alkondon, M;Braga, MFM;Albuquerque, EX
通讯作者：
Albuquerque, EX
DOI：
10.3109/10799899709036607
发表时间：
1997-01-01
期刊：
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
影响因子：
--
作者：
Albuquerque, EX;Pereira, EFR;Maelicke, A
通讯作者：
Maelicke, A
影响因子：
2
作者：
Adcock, C;Smith, GR;Sansom, MSP
通讯作者：
Sansom, MSP
影响因子：
4.7
作者：
Alkondon, M;Pereira, EFR;Albuquerque, EX
通讯作者：
Albuquerque, EX
影响因子：
2.5
作者：
Alkondon, M;Albuquerque, EX
通讯作者：
Albuquerque, EX