GENETIC-FACTORS IN GRAVES OPHTHALMOPATHY
GENETIC-FACTORS IN GRAVES OPHTHALMOPATHY
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DOI：
10.1111/j.1365-2265.1986.tb03599.x
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发表时间：
1986-11-01
影响因子：
3.2
通讯作者：
FARID, NR
中科院分区：
文献类型：
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作者：
FRECKER, M;STENSZKY, V;FARID, NR
我们调查了117例Graves病患者、62例眼病患者和55例非Graves病患者的HLA和免疫球蛋白G重链标记（Gm）的分布。就Graves病本身而言，与HLA-DR 3的关系比与B8的关系更密切。Graves眼病患者的情况正好相反（B8和DR 3相关眼病的比值比分别为12.4和7.7，P均< 0.0005）。HLA-DR 7与B8相互作用改变眼病的风险;使用表型B8-DR 7-作为参考，B8+ DR 7+的比值比为16.7，B8+ DR 7-为8.7，B8-DR 7+为0.26。因此，DR 7在B8+存在时增加了眼病的风险，但在B8+不存在时具有保护作用。尽管GM与眼病无关，但它改变了与HLA-B8相关的眼病的风险; B8+ Gmfb纯合性（fb+）的比值比为20.9，B8+ fb-为15.3，B8- fb+为1.7（B8- fb- = 1.00）。我们的结论是，遗传因素导致的Graves眼病是不同的，从那些有关的责任Graves甲亢。
We investigated the distribution of HLA and immunoglobulin G heavy chain markers (Gm) in 117 patients with Graves'' disease, 62 with ophthalmopthy and 55 without. With Graves'' disease per se, there is a closer association with HLA-DR3 than with B8. The opposite was true for Graves'' patients with ophthalmopathy (odds ratio for ophthalmopathy associated with B8 was 12.4 and with DR3 was 7.7, both with P < 0.0005). HLA-DR7 interacts with B8 in modifying the risk for eye disease; using the phenotype B8- DR7- as reference, the odds ratios were 16.7 for B8+ DR7+, 8.7 for B8+ DR7- and 0.26 for B8- DR7+. Thus, DR7 enhanced the risk for ophthalmopathy in the presence of B8+ but had a protective influence in its absence. Although Gm showed no association with eye disease, it modified the risk for ophthalmopathy associated with HLA-B8; the odds ratios were 20.9 for B8+ Gmfb homozygosity (fb+), 15.3 for B8+ fb- and 1.7 for B8- fb+ (B8- fb- = 1.00). We conclude that the genetic factors contributing to Graves'' ophthalmopathy are different from those related to liability for Graves'' hyperthyroidism.