A novel perivascular cell population in the zebrafish brain
A novel perivascular cell population in the zebrafish brain
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DOI：
10.7554/elife.24369
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发表时间：
2017-04-11
期刊：
影响因子：
7.7
通讯作者：
Weinstein, Brant M.
中科院分区：
文献类型：
--
作者：
Galanternik, Marina Venero;Castranova, Daniel;Weinstein, Brant M.
血脑屏障对中枢神经系统正常的稳态和功能是必不可少的，但其作用机制尚不清楚。脑血管周围的血管周围细胞被认为对血脑屏障的建立很重要，但它们的作用尚未很好地确定。在这里，我们描述了一种新的与斑马鱼大脑中的血管密切相关的血管周围细胞群。根据它们在形态、位置和清道夫行为上的相似之处，这些细胞似乎是斑马鱼的等价物，其特征不同地表现为哺乳动物的荧光颗粒周围皮细胞(FGP)、血管周围巨噬细胞或‘Mato细胞’。尽管斑马鱼FGPs具有巨噬细胞样的形态和血管周围的位置，但在分子上看起来与淋巴管内皮细胞最相似，我们的成像研究表明，这些细胞是从视脉络血管丛的内皮分化而来的。我们的发现首次报道了脑部血管周围细胞来源于血管内皮细胞。
The blood-brain barrier is essential for the proper homeostasis and function of the CNS, but its mechanism of function is poorly understood. Perivascular cells surrounding brain blood vessels are thought to be important for blood-brain barrier establishment, but their roles are not well defined. Here, we describe a novel perivascular cell population closely associated with blood vessels on the zebrafish brain. Based on similarities in their morphology, location, and scavenger behavior, these cells appear to be the zebrafish equivalent of cells variably characterized as Fluorescent Granular Perithelial cells (FGPs), perivascular macrophages, or 'Mato Cells' in mammals. Despite their macrophage-like morphology and perivascular location, zebrafish FGPs appear molecularly most similar to lymphatic endothelium, and our imaging studies suggest that these cells emerge by differentiation from endothelium of the optic choroidal vascular plexus. Our findings provide the first report of a perivascular cell population in the brain derived from vascular endothelium.