SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values.
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values.
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DOI：
10.3389/fmolb.2021.714203
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发表时间：
2021
影响因子：
5
通讯作者：
Tian Z
中科院分区：
文献类型：
--
作者：
Han Z;Zhuang X;Yang B;Jin L;Hong P;Xue J;Chen S;Tian Z
目的：神经胶质瘤仍然是世界范围内严重的公共卫生问题之一，需要进一步深入的研究。本研究的目的是通过公共数据库分析和体外验证来探讨突触缺陷蛋白1同源物1 （SYDE1）与胶质瘤之间的关系，以确定潜在的诊断和预后价值。方法与结果：与健康脑组织相比，胶质瘤组织中SYDE1的表达明显升高。此外，SYDE1在具有不利临床病理因素的胶质瘤患者中表达水平较高。体外敲低SYDE1可抑制胶质瘤细胞系A172的迁移和侵袭能力，但不影响其增殖能力。与SYDE1共表达的前100个基因的GO和KEGG通路分析显示肿瘤相关术语丰富。进一步的生物信息学分析显示，SNHG16/hsa-miR-520e/SYDE1轴可能参与胶质瘤的发展。结论：SYDE1在胶质瘤中的表达水平高于正常脑组织，可促进胶质瘤的转移和侵袭，但不促进胶质瘤的增殖。此外，SYDE1在胶质瘤的诊断和预后预测中具有一定的价值。
Objectives: Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 (SYDE1) and gliomas via public database analysis and in vitro validation to determine the potential diagnostic and prognostic values. Methods and Results: Compared with healthy brain tissues, there was a significant increase in SYDE1 expression in glioma tissues. Additionally, SYDE1 exhibited higher expression levels in glioma patients with unfavorable clinicopathological factors. In vitro knockdown of SYDE1 in glioma cell lines A172 inhibited their migrative and invasive ability but not the proliferative ability. GO and KEGG pathway analysis of the top 100 genes coexpressed with SYDE1 showed enrichments of tumor-associated terms. Further bioinformatic analysis revealed that the SNHG16/hsa-miR-520e/SYDE1 axis might be involved in glioma development. Conclusions: SYDE1 is expressed at higher levels in gliomas than in healthy brains, and can promote metastasis and invasion but not proliferation of gliomas. Furthermore, SYDE1 has values in the diagnosis and prognosis prediction of gliomas.