Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD
Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD
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DOI：
10.1136/thorax.58.4.294
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发表时间：
2003-04-01
期刊：
影响因子：
10
通讯作者：
Barnes, PJ
中科院分区：
文献类型：
--
作者：
Biernacki, WA;Kharitonov, SA;Barnes, PJ
背景：病情加重是慢性阻塞性肺疾病(COPD)的重要特征，占医疗费用的很大比例。方法：检测21例COPD患者(11例)急性加重期和抗生素治疗2周后呼气冷凝液中白三烯B4(LTB4)和8-异前列腺素(8-Iisprostane)的浓度。结果：LTB4在COPD急性加重期升高，平均(SE)15.8(1.1)pg/ml，经抗生素治疗后降至9.9(0.9)pg/ml(P<0.05)。
Background: Exacerbations are an important feature of chronic obstructive pulmonary disease (COPD), accounting for a large proportion of health care costs. They are associated with increased airway inflammation and oxidative stress.Methods: Concentrations of leukotriene B4 (LTB4), a marker of inflammation, and 8-isoprostane, a marker of oxidative stress, were measured in the exhaled breath condensate of 21 patients (11 M) with COPD during an exacerbation and 2 weeks after treatment with antibiotics. In 12 patients who had no further exacerbations these markers were also measured after 2 months.Results: LTB4 concentrations were raised during the COPD exacerbation (mean (SE) 15.8 (1.1) pg/ml and fell after treatment with antibiotics to 9.9 (0.9) pg/ml (p