Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice
Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice
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DOI：
10.1007/s10519-005-3423-9
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发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Plomin, R
中科院分区：
文献类型：
--
作者：
Galsworthy, MJ;Paya-Cano, JL;Plomin, R
该报告包括对小鼠行为的首次兄弟姐妹研究，并提供了遗传的一般认知能力(g)因素影响认知电池的证据。报告了来自雄性和雌性近亲繁殖小鼠群体（n = 84）的数据，以及对雄性兄弟姐妹对（n = 167）的复制研究。使用的竞技场有t型迷宫、莫里斯水迷宫、拼图盒、赫布-威廉姆斯迷宫、物体探索、水加迷宫和第二个食物拼图竞技场。结果显示，该因子结构与g在小鼠体内的存在一致。在第一项研究中，这个因素占41%的方差（在性别回归后为36%），在第二项研究中占23%，在第二项研究中，这个因素也显示出0.17-0.21的兄弟姐妹相关性，这意味着遗传率的上限估计约为40%。许多任务的可靠性很低，因此设置了更低的领域间或兄弟相关性的上限。尽管如此，该因子结构被认为在电池成分的排列中仍然相当稳健，目前的发现与最近的其他研究非常吻合。
This report includes the first sibling study of mouse behavior, and presents evidence for a heritable general cognitive ability (g) factor influencing cognitive batteries. Data from a population of male and female outbred mice (n = 84), and a replication study of male sibling pairs (n = 167) are reported. Arenas employed were the T-maze, the Morris water maze, the puzzle box, the Hebb-Williams maze, object exploration, a water plus-maze, and a second food-puzzle arena. The results show a factor structure consistent with the presence of g in mice. Employing one score per arena, this factor accounts for 41% of the variance in the first study (or 36% after sex regression) and 23% in the second, where this factor also showed sibling correlations of 0.17-0.21, which translates into an upper-limit heritability estimate of around 40%. Reliabilities of many tasks are low and consequently set an even lower ceiling for inter-arena or sibling correlations. Nevertheless, the factor structure is seen to remain fairly robust across permutations of the battery composition and the current findings fit well with other recent studies.