Three-dimensional ultrashort echo time cones T1ρ (3D UTE-cones-T1ρ) imaging
Three-dimensional ultrashort echo time cones T1ρ (3D UTE-cones-T1ρ) imaging
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DOI：
10.1002/nbm.3709
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发表时间：
2017-06-01
影响因子：
2.9
通讯作者：
Du, Jiang
中科院分区：
文献类型：
--
作者：
Ma, Ya-Jun;Carl, Michael;Du, Jiang
我们报告了一种新颖的三维（3D）超短回波时间（UTE）序列，采用 Cones 轨迹和 T-1 准备（UTE-Cones-T-1）对肌肉骨骼系统中的短 T-2 组织进行定量 T-1 评估。基本的 3D UTE-Cones 序列与用于 T-1 对比的自旋锁定准备脉冲相结合。使用相对较短的 TR 来减少扫描时间，这需要使用具有可变 TR 的 3D UTE-Cones 数据采集进行 T-1 测量和补偿。减少总扫描时间的另一种策略是在每次 T-1 准备和脂肪饱和后获取多个 Cones 辐条 (N-sp)。在 12 分钟内获得四个自旋锁定时间 (TSL=0-20ms)，另外还需要 7 分钟进行 T-1 测量。使用临床 3-T 扫描仪，将 3D UTE-Cones-T-1 序列与二维 (2D) 螺旋 T-1 序列进行比较，以对球形 CuSO4 模型、离体半月板和肌腱标本以及健康志愿者的膝关节和踝关节进行成像。 CuSO4 模型显示，2D 螺旋-T-1 序列的 T-1 值为 76.5 +/- 1.6ms，N-sp 为 1 和 5 的 3D UTE-Cones-T-1 序列的 T-1 值分别为 85.7 +/- 3.6 和 89.2 +/- 1.4ms。相对于 2D 螺旋 T-1 序列，3D UTE-Cones-T-1 序列为牛半月板样品提供了更短的 T-1 值（分别为 10-12 毫秒和 16 毫秒）。人类尸体跟腱样本只能使用 3D UTE-Cones-T-1 序列（T-1=4.0 +/- 0.9ms）进行成像，而 2Dspiral-T-1 序列则显示出接近零的信号强度。人体研究得出的关节软骨、半月板和跟腱的 T-1 值分别为 36.1 +/- 2.9、18.3 +/- 3.9 和 3.1 +/- 0.4 毫秒。 3D UTE-Cones-T-1 序列允许对体内短 T-2 组织进行体积 T-1 测量。
We report a novel three-dimensional (3D) ultrashort echo time (UTE) sequence employing Cones trajectory and T-1 preparation (UTE-Cones-T-1) for quantitative T-1 assessment of short T-2 tissues in the musculoskeletal system. A basic 3D UTE-Cones sequence was combined with a spin-locking preparation pulse for T-1 contrast. A relatively short TR was used to decrease the scan time, which required T-1 measurement and compensation using 3D UTE-Cones data acquisitions with variable TRs. Another strategy to reduce the total scan time was to acquire multiple Cones spokes (N-sp) after each T-1 preparation and fat saturation. Four spin-locking times (TSL=0-20ms) were acquired over 12min, plus another 7min for T-1 measurement. The 3D UTE-Cones-T-1 sequence was compared with a two-dimensional (2D) spiral-T-1 sequence for the imaging of a spherical CuSO4 phantom and ex vivo meniscus and tendon specimens, as well as the knee and ankle joints of healthy volunteers, using a clinical 3-T scanner. The CuSO4 phantom showed a T-1 value of 76.5 +/- 1.6ms with the 2D spiral-T-1 sequence, as well as 85.7 +/- 3.6 and 89.2 +/- 1.4ms for the 3D UTE-Cones-T-1 sequences with N-sp of 1 and 5, respectively. The 3D UTE-Cones-T-1 sequence provided shorter T-1 values for the bovine meniscus sample relative to the 2D spiral-T-1 sequence (10-12ms versus 16ms, respectively). The cadaveric human Achilles tendon sample could only be imaged with the 3D UTE-Cones-T-1 sequence (T-1=4.0 +/- 0.9ms), with the 2D spiral-T-1 sequence demonstrating near-zero signal intensity. Human studies yielded T-1 values of 36.1 +/- 2.9, 18.3 +/- 3.9 and 3.1 +/- 0.4ms for articular cartilage, meniscus and the Achilles tendon, respectively. The 3D UTE-Cones-T-1 sequence allows volumetric T-1 measurement of short T-2 tissues in vivo.