Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
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DOI：
10.1542/neo.22-9-e606
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发表时间：
2021-09-01
期刊：
影响因子：
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通讯作者：
Mithal, Leena B
中科院分区：
文献类型：
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作者：
Jenks, Carolyn M;Hoff, Stephen R;Mithal, Leena B
先天性巨细胞病毒 (cCMV) 感染很常见，因为该病毒无处不在，而且怀孕期间缺乏有效的预防策略。大多数患有 cCMV 的婴儿没有症状，但其中一个值得注意的子集可能会产生后遗症，包括最常见的感音神经性听力损失和神经发育障碍，这些在出生时可能不存在。在出生后最初几周及时筛查巨细胞病毒对于正确诊断先天性感染、评估受影响的婴儿和确定治疗方案至关重要。缬更昔洛韦抗病毒治疗可以优化有症状婴儿的最终听力和神经发育结果。本综述讨论了 cCMV 的流行病学和临床表现、有针对性和通用的筛查方法以及 cCMV 婴儿的治疗和监测。
Congenital cytomegalovirus (cCMV) infection is common because of the ubiquitous nature of the virus and the lack of an effective prevention strategy during pregnancy. Most infants with cCMV are asymptomatic, although a notable subset can have sequelae including, most commonly, sensorineural hearing loss and neurodevelopmental disability, which may not be present at birth. Timely screening for cytomegalovirus in the first weeks after birth is critical to appropriately diagnose congenital infection, evaluate affected infants, and determine the treatment course. Antiviral therapy with valganciclovir can optimize end hearing and neurodevelopmental outcomes in symptomatic infants. This review discusses the epidemiology and clinical manifestations of cCMV, targeted and universal screening approaches, and treatment and monitoring of infants with cCMV.