HISTOGENESIS OF DOPAMINE-CONTAINING NEURONS IN THE RAT RETINA
HISTOGENESIS OF DOPAMINE-CONTAINING NEURONS IN THE RAT RETINA
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DOI：
10.1016/s0014-4835(87)80174-4
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发表时间：
1987-03-01
影响因子：
3.4
通讯作者：
BATTELLE, BA
中科院分区：
文献类型：
--
作者：
EVANS, JA;BATTELLE, BA
在发育过程中，中枢神经系统中的神经元停止分裂是分化的关键早期步骤，这可能是表型表达的先决条件。在这项双标签研究中，我们将[3H]胸苷放射自显影与内源性多巴胺的组织化学检测相结合，研究了大鼠视网膜无分泌层含多巴胺细胞（da细胞）的组织发生。我们发现，成年大鼠视网膜中的大多数da细胞在胚胎16天和20天之间停止分裂。这些结果表明，大多数注定成为多巴胺能神经元的细胞是在无突细胞产生的延长期内的一个离散间隔内产生的，这些细胞是在胚胎视网膜中产生的。
The point during development when a neuron in the central nervous system ceases to divide is a crucial early step in differentiation which may be a prerequisite for phenotypic expression. In this double-label study, which combines [3H]thymidine autoradiography with histochemical detection of endogenous dopamine, we examined the histogenesis of dopamine-containing cells (DA-cells) in the amacrine layer of the rat retina. We found that most DA-cells present in the adult rat retina stop dividing between embryonic days 16 and 20. These results show that most cells destined to become dopaminergic neurons are generated during a discrete interval within the extended period of amacrine-cell production, and that these cells are produced in the embryonic retina.