Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome
Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome
复制标题
DOI：
10.1111/bjh.16522
复制
发表时间：
2020-02-20
影响因子：
6.5
通讯作者：
Kumar, Shaji
中科院分区：
文献类型：
--
作者：
Kourelis, Taxiarchis V.;Jevremovic, Dragan;Kumar, Shaji
我们试图使用质谱仪分析一小群（N = 10）POEMS患者在诊断时和治疗后的肿瘤微环境。我们纳入了10例MGUS患者作为对照。我们在CD 45（+）和CD 3（+）区室中鉴定了29个免疫细胞亚群。新诊断/进展POEMS患者骨髓中双阳性T细胞和PD-1阳性CD 4 T细胞扩增，初始CD 4 T细胞减少。这些发现为可能的抗原驱动选择作为POEMS疾病发病机制的驱动因素提供了证据。
We sought to dissect the tumour microenvironment in a small cohort (N = 10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45(+) and CD3(+) compartments. Double positive T cells and PD-1 positive CD4 T cells were expanded and naive CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic-driven selection as a driver of disease pathogenesis in POEMS.