REGIONAL ISCHEMIC PRECONDITIONING PROTECTS REMOTE VIRGIN MYOCARDIUM FROM SUBSEQUENT SUSTAINED CORONARY-OCCLUSION
REGIONAL ISCHEMIC PRECONDITIONING PROTECTS REMOTE VIRGIN MYOCARDIUM FROM SUBSEQUENT SUSTAINED CORONARY-OCCLUSION
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DOI：
10.1161/01.cir.87.3.893
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发表时间：
1993-03-01
期刊：
影响因子：
37.8
通讯作者：
WHITTAKER, P
中科院分区：
文献类型：
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作者：
PRZYKLENK, K;BAUER, B;WHITTAKER, P
背景一次或多次短暂的冠状动脉闭塞可以保护或“预处理”由该动脉灌注的心肌，使其免受随后的持续缺血。我们试图确定缺血预处理是否只保护那些心肌细胞进行短暂的冠状动脉闭塞或是否短暂闭塞在一个血管床也限制梗死面积和/或减弱收缩功能障碍，在远程处女心肌进行后续的持续coronaryocclusion.Methods和结果。在该研究的初步分支中，6只麻醉的狗经历了4次5分钟的回旋支分支闭塞加5分钟的再灌注，随后是1小时的持续左前降支冠状动脉闭塞和4.5小时的再灌注。左前降支冠状动脉闭塞期间的心内膜下血流（通过注射放射性标记微球测量）为0.07+/-0.03 mL。min-1。g组织-1，类似于0.07+/-0.02 mL的值。min-1。g-1，在一组8只并行对照犬中观察到。然而，回旋支预处理组的梗死面积（通过三苯基四氮唑染色评估）平均为危险心肌的4+/-1%，显著低于（p
Background. One or more brief episodes of coronary artery occlusion protect or ''precondition'' the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief occlusions in one vascular bed also limit infarct size and/or attenuate contractile dysfunction in remote virgin myocardium subjected to subsequent sustained coronary occlusion.Methods and Results. In the preliminary limb of the study, six anesthetized dogs underwent four episodes of 5-minute circumflex branch occlusion plus 5-minute reperfusion, followed by 1 hour of sustained left anterior descending coronary artery occlusion and 4.5 hours of reflow. Subendocardial blood flow during left anterior descending coronary artery occlusion (measured by injection of radiolabeled microspheres) was 0.07+/-0.03 mL . min-1 . g tissue-1 , similar to the value of 0.07+/-0.02 mL . min-1 . g-1 observed in a group of eight concurrent control dogs. However, infarct size (assessed by triphenyltetrazolium staining) in the circumflex preconditioned group averaged 4+/-1% of the myocardium at risk, significantly less (p