MYC in Regulating Immunity: Metabolism and Beyond.
MYC in Regulating Immunity: Metabolism and Beyond.
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DOI：
10.3390/genes8030088
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发表时间：
2017-02-25
期刊：
影响因子：
3.5
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Gnanaprakasam JN;Wang R
骨髓细胞瘤病癌基因(MYC)家族成员，包括细胞性MYC(c-Myc)、神经母细胞瘤来源的MYC(MYCN)和肺癌来源的MYC(MYCL)，都被认为是广泛的人类癌症的关键致癌因素。除了癌症，MYC在其他生理和病理过程中也发挥着重要作用，即免疫和免疫性疾病。MYC在很大程度上是作为一种转录因子，促进许多靶基因的表达，在细胞、组织和器官水平上协调死亡、增殖和新陈代谢。已有研究表明，MYC家族成员在发育过程中或在免疫刺激下，其表达在免疫细胞中受到严格调控。新的证据表明，MYC家族成员在调节免疫细胞的发育、分化和激活方面发挥着重要作用。通过在免疫细胞中驱动一系列代谢基因的表达，MYC家族成员协调代谢程序以支持免疫功能。在这里，我们讨论我们对免疫系统中MYC生物学的理解，以及MYC的调节如何影响免疫代谢和反应。
Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derived MYC (MYCN), and lung carcinoma derived MYC (MYCL), have all been implicated as key oncogenic drivers in a broad range of human cancers. Beyond cancer, MYC plays an important role in other physiological and pathological processes, namely immunity and immunological diseases. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. It has been shown that the expression of MYC family members is tightly regulated in immune cells during development or upon immune stimulations. Emerging evidence suggests that MYC family members play essential roles in regulating the development, differentiation and activation of immune cells. Through driving the expression of a broad range of metabolic genes in immune cells, MYC family members coordinate metabolic programs to support immune functions. Here, we discuss our understanding of MYC biology in immune system and how modulation of MYC impacts immune metabolism and responses.