Antimicrobial activity of ruthenium-based intercalators
Antimicrobial activity of ruthenium-based intercalators
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DOI：
10.1016/j.ejps.2010.12.004
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发表时间：
2011-03-18
影响因子：
4.6
通讯作者：
Aldrich-Wright, Janice
中科院分区：
文献类型：
--
作者：
Bolhuis, Albert;Hand, Lorna;Aldrich-Wright, Janice
细菌病原体的多重耐药性是一个主要问题，显然需要开发新型抗生素。在这里，我们研究了钌（II）为基础的DNA嵌入配合物的抗菌活性。发现这些复合物在体外对革兰氏阴性细菌大肠杆菌没有活性，但复合物对革兰氏阳性细菌枯草芽孢杆菌和金黄色葡萄球菌明显有活性。使用简单的感染模型，线虫秀丽隐杆线虫，也证明了化合物之一的体内活性。重要的是，这也表明测试的化合物对线虫没有毒性。(C)2010 Elsevier B.V.保留所有权利。
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coli, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes. (C) 2010 Elsevier B.V. All rights reserved.