Relationship Between Alcohol Consumption and Serum Lipid Profiles Among Middle-Aged Population in China: A Multiple-Center Cardiovascular Epidemiological Study
Relationship Between Alcohol Consumption and Serum Lipid Profiles Among Middle-Aged Population in China: A Multiple-Center Cardiovascular Epidemiological Study
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DOI：
10.1177/0003319714549557
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发表时间：
2015-09-01
期刊：
影响因子：
2.8
通讯作者：
Zhu, Manlu
中科院分区：
文献类型：
--
作者：
Hao, Guang;Wang, Zengwu;Zhu, Manlu
我们评估了中国中年人群的饮酒量与血脂之间的关系。 10 154 名参与者的总体饮酒率为男性 34.07%，女性 3.61%。重度饮酒者（每天 30 克）往往年龄较大、吸烟者、高血压患者、从事剧烈体力活动且体重指数较低。随着男性饮酒量的增加，高密度脂蛋白胆固醇（HDL-C）、载脂蛋白（apo）A1、低密度脂蛋白胆固醇-HDL-C比值和apo B-apo A1比值升高。在控制所有混杂因素后，与戒酒者相比，每天饮酒 30 g 的男性饮酒者的甘油三酯增加了 0.27 mmol/L，脂蛋白（a）、Lp(a) 降低了 2.10 mg/dL。男女总胆固醇、HDL-C 和 apo A1 水平随着酒精摄入量的增加而增加，而男性 Lp(a) 水平则随着酒精摄入量的增加而降低。
We assessed the relationship between alcohol consumption and serum lipids in a middle-aged Chinese population. The overall prevalence of drinking among 10 154 participants was 34.07% in males and 3.61% in females. Heavy alcohol drinkers ( 30 g/d) tended to be older, smokers, hypertensive, do heavy physical activity, and have a lower body mass index. Levels of high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) A1, low-density lipoprotein cholesterol-HDL-C ratio, and apo B-apo A1 ratio rose with increase in alcohol intake in males. An increase of 0.27 mmol/L in triglycerides and a decrease of 2.10 mg/dL in lipoprotein(a), Lp(a), were observed in male alcohol drinkers who consumed 30 g alcohol/d compared with abstainers after controlling for all confounders. Levels of total cholesterol, HDL-C, and apo A1 increased with increase in alcohol intake in both genders and Lp(a) decreased with the increase in alcohol intake in males.