Crystal and molecular structure of a histo-blood group antigen involved in cell adhesion: The Lewis x trisaccharide

Crystal and molecular structure of a histo-blood group antigen involved in cell adhesion: The Lewis x trisaccharide
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DOI:
10.1093/glycob/6.5.537
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发表时间:
1996-07-01
期刊:
影响因子:
4.3
通讯作者:
Imberty, A
Imberty, A
中科院分区:
生物学3区
文献类型:
--
作者:
Perez, S;MouhousRiou, N;Imberty, A

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这项工作描述了有史以来第一次报道的组织血型碳水化合物抗原的晶体结构:Le(x),这项研究提供了两个晶体学独立分子在高度水合环境中的构象的详细描述,沿着它们的氢键性质和堆积特征,在相邻的三聚体之间观察到的一些相互作用可以为Le(x)-Le(x)相互作用参与细胞-细胞粘附提供基础。
This work describes the first crystal structure ever reported of a histo-blood group carbohydrate antigen: Le(x), This study provides a detailed description of the conformation of two crystallographic independent molecules in a highly hydrated environment along with their hydrogen bonding properties and packing features, Some interactions observed between adjacent trisaccharides can provide the basis for involvement of Le(x)-Le(x) interactions in cell-cell adhesion.