Neonatal Vitamin D Status and Risk of Schizophrenia A Population-Based Case-Control Study
Neonatal Vitamin D Status and Risk of Schizophrenia A Population-Based Case-Control Study
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DOI：
10.1001/archgenpsychiatry.2010.110
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发表时间：
2010-09-01
影响因子：
--
通讯作者：
Mortensen, Preben B.
中科院分区：
文献类型：
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作者：
McGrath, John J.;Eyles, Darryl W.;Mortensen, Preben B.
内容：精神分裂症的流行病学线索表明，低水平的发育维生素D可能与精神分裂症的风险增加有关。目的：直接检查新生儿维生素D状况与精神分裂症风险之间的关系。设计：从基于人群的队列中抽取的个体匹配病例对照研究。设置：丹麦国家健康登记册和新生儿生物库。参与者：共有424名精神分裂症患者和424名对照组的性别和出生日期相匹配。主要结果措施：25羟基维生素D-3（25 [OH] D3）的浓度进行了评估，从新生儿干血样使用高灵敏度液相色谱串联质谱法。结果：与25 [OH] D3浓度在40.5 ~ 50.9nmol/L之间的第四个五分位数的新生儿相比，低三个五分位数的新生儿患精神分裂症的危险性显著增加（增加2倍）。出乎意料的是，那些处于最高五分位数的人患精神分裂症的风险也显著增加。基于这一分析，与新生儿维生素D状况相关的人群归因分数为44%。广泛的潜在的混杂或相互作用的variables.Conclusions：新生儿维生素D的低浓度和高浓度与精神分裂症的风险增加，这是可行的，这种接触可能有助于相当大比例的情况下，在丹麦。鉴于这一发现对公共卫生的重大影响，迫切需要进一步探讨维生素D状况对大脑发育和后期心理健康的影响。
Context: Clues from the epidemiology of Schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia.Objective: To directly examine the association between neonatal vitamin D status and risk of schizophrenia.Design: Individually matched case-control study drawn from a population-based cohort.Setting: Danish national health registers and neonatal biobank.Participants: A total of 424 individuals with schizophrenia and 424 controls matched for sex and date of birth.Main Outcome Measures: The concentration of 25 hydroxyvitamin D-3 (25 [OH] D3) was assessed from neonatal dried blood samples using a highly sensitive liquid chromatography tandem mass spectroscopy method. Relative risks were calculated for the matched pairs when examined for quintiles of 25(OH)D3.Results: Compared with neonates in the fourth quintile (with 25[OH]D3 concentrations between 40.5 and 50.9 nmol/L), those in each of the lower 3 quintiles had a significantly increased risk of schizophrenia (2-fold elevated risk). Unexpectedly, those in the highest quintile also had a significantly increased risk of schizophrenia. Based on this analysis, the population-attributable fraction associated with neonatal vitamin D status was 44%. The relationship was not explained by a wide range of potential confounding or interacting variables.Conclusions: Both low and high concentrations of neonatal vitamin D are associated with increased risk of schizophrenia, and it is feasible that this exposure could contribute to a sizeable proportion of cases in Denmark. In light of the substantial public health implications of this finding, there is an urgent need to further explore the effect of vitamin D status on brain development and later mental health.