COMPUTATIONS UNDERLYING THE EXECUTION OF MOVEMENT - A BIOLOGICAL PERSPECTIVE
COMPUTATIONS UNDERLYING THE EXECUTION OF MOVEMENT - A BIOLOGICAL PERSPECTIVE
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DOI：
10.1126/science.1857964
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发表时间：
1991-07-19
期刊：
影响因子：
56.9
通讯作者：
GISZTER, S
中科院分区：
文献类型：
--
作者：
BIZZI, E;MUSSAIVALDI, FA;GISZTER, S
为了执行自主运动，中枢神经系统必须将由皮层和皮层下神经元的活动所代表的肢体运动的方向、幅度和速度的神经表征转化为激活肢体运动肌肉的信号。这个任务相当于解决一个“病态”的计算问题，因为肌肉骨骼装置的自由度比行动计划中规定的要大得多。一些机制和电路基础的运动计划转化为运动命令的描述。这种转变的一个主要特征是脊髓运动前区肢体姿势的粗略图。在脊髓图谱的不同区域之间运动输出的矢量组合可能产生大量的运动行为。
To execute voluntary movements, the central nervous system must transform the neural representation of the direction, amplitude, and velocity of the limb, represented by the activity of cortical and subcortical neurons, into signals that activate the muscles that move the limb. This task is equivalent to solving an "ill-posed" computational problem because the number of degrees of freedom of the musculoskeletal apparatus is much larger than that specified in the plan of action. Some of the mechanisms and circuitry underlying the transformation of motor plans into motor commands are described. A central feature of this transformation is a coarse map of limb postures in the premotor areas of the spinal cord. Vectorial combination of motor outputs among different areas of the spinal map may produce a large repertoire of motor behaviors.