Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent.
Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent.
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DOI：
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发表时间：
1998-03
期刊：
影响因子：
2.2
通讯作者：
R. M. P. Hopp;N. Ransom;S. Hilsenbeck;D. Papermaster;J. Windle
中科院分区：
文献类型：
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作者：
R. M. P. Hopp;N. Ransom;S. Hilsenbeck;D. Papermaster;J. Windle
目的研究p53是否介导视网膜变性（rd1）小鼠光感受器的凋亡。方法将rd1/rd1小鼠与p53基因敲除小鼠杂交，制备p53-/-rd1/rd1和p53 +/+ rd1/rd1小鼠。在适当的年龄（出生后第12、14和16天）分析视杆细胞光感受器的损失率和凋亡发生率。结果：rd1小鼠光感受器细胞丢失的程度和动力学在p53 +/+和p53缺失小鼠中几乎没有区别。结论：在rd1小鼠模型中，感光细胞凋亡主要通过p53非依赖性分子途径发生。
PURPOSE To determine if p53 mediates apoptosis in photoreceptors of retinal degeneration, rd1, mice. METHODS The rd1/rd1 mice were interbred with p53 null mice to generate p53-/- rd1/rd1 and p53+/+ rd1/rd1 mice. Rates of loss and incidence of apoptosis in rod photoreceptors were analyzed at appropriate ages (postnatal days 12, 14 and 16). RESULTS The extent and kinetics of photoreceptor cell loss in rd1 mice were nearly indistinguishable in the p53+/+ and p53 null mice. CONCLUSIONS Photoreceptor cell apoptosis in the rd1 mouse model occurs by a predominantly p53-independent molecular pathway.