The Na-K-ATPase and calcium-signaling microdomains.
The Na-K-ATPase and calcium-signaling microdomains.
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DOI：
10.1152/physiol.00008.2008
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Xie ZJ
中科院分区：
文献类型：
--
作者：
Tian J;Xie ZJ
Na/K-ATP 酶是一种能量转换离子泵，可将 ATP 的自由能转化为跨膜离子梯度。它还充当强心类固醇（如哇巴因和地高辛）的功能受体。哇巴因与 Na/K-ATP 酶的结合可以以细胞特异性方式激活钙信号传导。通过 Na/K-ATP 酶进行精细的钙调节是通过泵整合来自众多蛋白质和非蛋白质分子（包括离子转运蛋白、通道、蛋白激酶/磷酸酶以及细胞 Na+）的信号的能力来实现的。本综述重点关注 Na/K-ATP 酶的独特性质及其在不同钙信号微结构域形成中的作用。
The Na/K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into trans-membrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na/K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na/K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na/K-ATPase and its role in the formation of different calcium signaling microdomains.