Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy:: Association with growth failure, Giardia lamblia, and intestinal permeability
Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy:: Association with growth failure, Giardia lamblia, and intestinal permeability
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DOI：
10.1097/00005176-200408000-00005
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发表时间：
2004-08-01
影响因子：
2.9
通讯作者：
Jeffries, DJ
中科院分区：
文献类型：
--
作者：
Campbell, DI;McPhail, G;Jeffries, DJ
目的：调查冈比亚肠病儿童的粪便新蝶呤浓度（肠道炎症的潜在标志物）是否与生长障碍相关。次要结果的措施测试贾第鞭毛虫感染，粪便新蝶呤和乳果糖甘露醇吸收率（L：M），肠permeability.Methods措施之间的关联：72名儿童的身高和体重测量，每6至8周，直到15个月的年龄在冈比亚农村村庄。在这些时间测量L：M比率、小肠渗透性和粪便新蝶呤的量度。结果：长期的身高和体重增长与受试者粪便中新蝶呤的平均浓度呈负相关（r分别为-0.29和-0.36; P < 0.001）。粪便新蝶呤与肠道通透性或腹泻史无相关性。在72名儿童中，19名粪便中有贾第虫囊肿，38名粪便检查阴性。感染儿童平均每周腹泻0.7天（95%置信区间[CI]，0.31-1.03），而未感染儿童为0.8天/周（95% CI，0.71-0.85）。粪便涂片阳性或阴性的受试者的生长情况无差异。两组的平均L：M比值相同（0.31; 95%CI，0.26-0.34）。结论：与热带婴儿肠道炎症可能损害生长的理论一致，粪便新蝶呤浓度与生长呈负相关。贾第虫以外的因素导致冈比亚婴儿肠病和生长障碍。(C)2004年利平科特威廉姆斯威尔金斯。
Objectives: Investigate whether fecal neopterin concentration (a potential marker of gut inflammation) in Gambian children with enteropathy was associated with growth failure. Secondary outcome measures tested the associations between Giardia lamblia infestation, fecal neopterin and lactulose mannitol absorption ratio(L:M), a measure of intestinal permeability.Methods: Seventy-two children had height and weight measured every 6 to 8 weeks until 15 months of age in a rural Gambian village. L:M ratio, a measure of small intestinal permeability and fecal neopterin were measured at these times. Stool was examined by immunoflorescence and light microscope for Giardia cysts.Results: Long-term height and weight gains were negatively associated with mean subject fecal neopterin concentration (r = -0.29 and -0.36, respectively; P < 0.001). There was no correlation between fecal neopterin and intestinal permeability or history of diarrhea. Of 72 children studied, 19 had Giardia cysts in stool and 38 had negative stool examinations. Infected children had a mean of 0.7 days of diarrhea/week (95% confidence interval [CI], 0.31-1.03) versus 0.8 days/week (95% CI, 0.71-0.85) in uninfected children. No difference in growth was detected between those with positive or negative fecal smears. Mean L:M ratio was the same in both groups (0.31; 95% CI, 0.26-0.34).Conclusions: Consistent with the theory that intestinal inflammation in tropical infants may impair growth, fecal neopterin concentrations were inversely associated with growth. Factors other than Giardia are causing enteropathy and growth failure in Gambian infants. (C) 2004 Lippincott Williams Wilkins.