ADIPOSE-TISSUE THYMIDINE KINASE-ACTIVITY IN MAN
ADIPOSE-TISSUE THYMIDINE KINASE-ACTIVITY IN MAN
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DOI：
10.1203/00006450-198602000-00004
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发表时间：
1986-02-01
影响因子：
3.6
通讯作者：
GREENWOOD, MRC
中科院分区：
文献类型：
--
作者：
BAUM, D;BECK, RQ;GREENWOOD, MRC
在人类脂肪组织发育过程中研究了胸苷激酶活性。从 81 名年龄在 7 周至 60 岁之间的人的腹股沟中获取脂肪组织。没有人患有代谢或生长障碍。脂肪组织胸苷激酶活性在婴儿中最高，在成人中最低。胸苷激酶活性峰值出现在出生后早期，而在青春期前则出现较小的升高，这与人类前脂肪细胞增殖的假设时期一致。 相反，在成年期，即脂质负载细胞数量稳定的时期，胸苷激酶活性较低。尽管这些脂肪组织样本包括基质细胞和脂肪细胞，但数据支持这样的假设：婴儿早期的脂肪组织生长主要是细胞增殖的结果，并且婴儿期后很少发生细胞增殖，除了可能在青春期之前的短暂时期外。
Thymidine kinase activity was studied during human adipose tissue development. Adipose tissue was obtained from the groin in 81 persons, aged 7 wk through 60 yr. None had a metabolic or growth disorder. Adipose tissue thymidine kinase activity was highest in infants and lowest in adults. Peak thymidine kinase activity was seen in the early postnatal period and a lesser elevation was found in the preadolescent years, coinciding with hypothesized periods of proliferation of preadipocytes in man. In contrast, during adulthood, a time of stable lipid-laden cell number, thymidine kinase activity was lower. Although these adipose tissue samples include both stromal and fat cells, the data support the hypothesis that adipose tissue growth in early infancy is primarily the result of cellular proliferation, and that little cellular proliferation occurs after infancy, except possibly for a brief period prior to adolescence.