Progress in the treatment of adults with acute leukemia: review of regimens containing cytarabine studied by the Southwest Oncology Group.
Progress in the treatment of adults with acute leukemia: review of regimens containing cytarabine studied by the Southwest Oncology Group.
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成人急性白血病的治疗进展：西南肿瘤学组研究的含有阿糖胞苷的治疗方案的回顾。
DOI：
10.1001/archinte.1976.03630120035013
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发表时间：
1976
影响因子：
--
通讯作者：
E. Freireich
中科院分区：
文献类型：
--
作者：
G. Bodey;C. Coltman;J. Hewlett;E. Freireich
多年来，成人急性白血病的治疗一直是一种徒劳的冒险，使患者和医生都感到沮丧。很少有患者获得缓解，而且通常是短期缓解。然而，少数患者在很长一段时间内保持完全缓解，这对那些坚持尝试改善这种疾病治疗的研究人员来说是一种鼓励。在过去的十年中，两个主要的进展导致这些患者的预后有了实质性的改善。因此，对成人急性白血病积极治疗价值的怀疑不再合理。第一个重大进展是发现了新的抗白血病药物阿糖胞苷（阿糖胞苷）和蒽环类抗生素。第二个重大进展是联合化疗的引入。阿糖胞苷的初步评价西南肿瘤学组（SWOG）于1966年启动了阿糖胞苷的研究。第一项研究评估了
For many years the treatment of acute leukemia in adults was a fruitless venture that was discouraging to both patient and physician. Remissions were achieved infrequently and were usually of short duration. However, a few patients remained in complete remission for prolonged periods, serving as a source of encouragement to those investigators who persisted in their attempts to improve the therapy of this disease. During the past decade, two major advances have resulted in substantial improvement in the prognosis of these patients. Consequently, skepticism regarding the value of aggressive treatment of adults with acute leukemia is no longer justified. The first major advance was the discovery of the new antileukemic agents, cytarabine (arabinosyl cytosine) and the anthracycline antibiotics. The second major advance was the introduction of combination chemotherapy. Initial Evaluation of Cytarabine The Southwest Oncology Group (SWOG) initiated studies with cytarabine in 1966. The first study evaluated the efficacy of