Nonviral Vehicles for Gene Delivery
Nonviral Vehicles for Gene Delivery
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DOI：
10.1142/s1793984421300028
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
E. Warga;Brian Austin-Carter;N. Comolli;Jacob J Elmer
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文献类型：
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作者：
E. Warga;Brian Austin-Carter;N. Comolli;Jacob J Elmer
非病毒基因递送（NVGD）由于其较低的成本和较高的安全性而成为病毒基因递送在临床应用中的一种有吸引力的替代方案。各种有前途的非病毒载体正在开发中，包括阳离子聚合物，脂质，脂质聚合物杂化物（LPH）和无机纳米颗粒。然而，一些NVGD策略具有限制其采用的缺点，包括高毒性和低效率。这篇评论的重点是最常见的NVGD车辆，重点是该领域的最新发展。
Nonviral gene delivery (NVGD) is an appealing alternative to viral gene delivery for clinical applications due to its lower cost and increased safety. A variety of promising nonviral vectors are under development, including cationic polymers, lipids, lipid-polymer hybrids (LPHs) and inorganic nanoparticles. However, some NVGD strategies have disadvantages that have limited their adoption, including high toxicity and low efficiency. This review focuses on the most common NVGD vehicles with an emphasis on recent developments in the field.