Appearance and disappearance of functional gastrointestinal disorders in patients with eating disorders
Appearance and disappearance of functional gastrointestinal disorders in patients with eating disorders
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DOI：
10.1111/j.1365-2982.2010.01576.x
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发表时间：
2010-12-01
影响因子：
3.5
通讯作者：
Kellow, John
中科院分区：
文献类型：
--
作者：
Boyd, Catherine;Abraham, Suzanne;Kellow, John
背景：功能性胃肠疾病或“功能性胃肠疾病样”症状（fgid）常见于进食障碍（ED），但尚不清楚这些疾病是否随时间稳定。目的是评估ED患者fgid的转换，并将这种转换与体重指数（BMI）、ED行为和心理变量的变化联系起来。方法对73例ED患者（n = 73）在入院和12个月随访时个体FGID和区域FGID类别（食管、胃十二指肠、肠和肛肠）的存在进行模式和重复测量分析，使用患者变量之间BMI和ED行为的变化。主要结果：入院时功能性胃肠疾病患病率为97%，随访时为77%。唯一个体fgid随时间下降的是功能性胃灼热（入院53%，随访23%）和功能性吞咽困难（21%,7%）。在个体FGID和区域FGID类别的消失、持续和出现方面，患者存在显著差异。25例（34%）患者在随访中获得至少一种新的FGID区域分类。BMI、自我诱导呕吐、泻药使用、暴饮暴食、焦虑、抑郁、躯体化和个体或区域fgid的转换之间没有关系。功能性胃肠疾病在ED患者12个月后仍然很常见。然而，FGID发生了相当大的转换，并且新的FGID的出现并不局限于最初的FGID区域类别。fgid的转换与ED行为、心理变量或体重变化之间没有明显的关系。这些发现对ED患者FGIDs的临床评估和管理具有重要意义。
Background Functional gastrointestinal disorders or 'functional gastrointestinal disorder-like' symptoms (FGIDs) occur commonly in eating disorders (ED), but it is not known if these disorders are stable over time. The aims were to evaluate the turnover of FGIDs in patients with ED, and to relate this turnover to changes in body mass index (BMI), ED behaviors, and psychological variables. Methods Patterns and repeated measures analysis of presence of individual FGIDs and regional FGID categories (esophageal, gastroduodenal, bowel, and anorectal) in ED patients (n = 73) at admission to hospital and at 12-month follow-up, using change in BMI and ED behaviors as between patient variables. Key Results Functional gastrointestinal disorders prevalence was 97% at admission and 77% at follow-up. The only individual FGIDs to decrease over time were functional heartburn (admission 53%, follow-up 23%) and functional dysphagia (21%, 7%). There was significant patient variation in the disappearance, persistence, and appearance of both individual FGIDs and FGID regional categories. Twenty-five (34%) of patients acquired at least one new FGID regional category at follow-up. There was no relationship between changes in BMI, self-induced vomiting, laxative use, binge eating, anxiety, depression, somatization, and the turnover of individual or regional FGIDs. Conclusions & Inferences Functional gastrointestinal disorders remain common after 12 months in patients with an ED. Considerable turnover of the FGIDs occurs, however, and the appearance of new FGIDs is not restricted to the original FGID regional category. There is no apparent relationship between the turnover of the FGIDs and ED behaviors, psychological variables or body weight change. These findings have implications for the clinical evaluation and management of FGIDs in ED patients.