Specification of sensory neuron cell fate from the neural crest.
Specification of sensory neuron cell fate from the neural crest.
复制标题
神经嵴感觉神经元细胞命运的规范。
DOI：
10.1007/978-0-387-46954-6_10
复制
发表时间：
2006
影响因子：
--
通讯作者：
Ungos,JosetteM
中科院分区：
文献类型：
--
作者：
Raible,DavidW;Ungos,JosetteM
如何从最初同质的细胞群体中产生不同的细胞命运是发育生物学中的一个驱动问题。神经嵴就是这样一个细胞群，它能够产生一系列令人难以置信的衍生物。1功能和形式不同的细胞，如皮肤中的色素细胞或周围神经系统的神经元和神经胶质，都来自神经嵴。这些细胞是如何选择沿着不同的路线迁移，在胚胎的特定区域聚集并分化成特定的细胞类型的？这一章的重点是发展一个特定的神经嵴衍生物，感觉神经元，作为研究这些问题的细胞命运规范的模型。在头部，感觉神经元位于三叉神经节和鳃上神经节，而在躯干中，它们形成脊髓或背根神经节（DRG）。DRG的发展将是本次审查的主要焦点。背根神经节的神经元和神经胶质细胞来源于合并在脊髓外侧边缘的躯干神经嵴细胞（图1）。这些神经嵴细胞沿着沿着与神经嵴细胞相同的路线迁移，所述神经嵴细胞填充位于沿着背主动脉的自主交感神经节。不知何故，DRG前体必须决定停止并采取邻近脊髓的感觉命运，而不是继续成为自主神经节的一部分。此外，一旦背根神经节前体聚集在其最终位置，仍有许多命运的选择。成熟的背根神经节由许多具有不同形态和独特生化特性的神经元以及支持这些神经元的神经胶质细胞组成。
How distinct cell fates are generated from initially homogeneous cell populations is a driving question in developmental biology. The neural crest is one such cell population that is capable of producing an incredible array of derivatives.1 Cells as different in function and form as the pigment cells in the skin or the neurons and glia of the peripheral nervous system are all derived from neural crest. How do these cells choose to migrate along distinct routes, populate defined regions of the embryo and differentiate into specific cell types?This chapter focuses on the development of one particular neural crest derivative, sensory neurons, as a model for studying these questions of cell fate specification. In the head, sensory neurons reside in the trigeminal and epibranchial ganglia, while in the trunk they form the spinal or dorsal root ganglia (DRG). The development of the DRG will be the main focus of this review. The neurons and glia of the DRG derive from trunk neural crest cells that coalesce at the lateral edge of the spinal cord (Fig. 1). These neural crest cells migrate along the same routes as neural crest cells that populate the autonomic sympathetic ganglia located along the dorsal aorta. Somehow DRG precursors must make the decision to stop and adopt a sensory fate adjacent to the spinal cord rather than continuing on to become part of the autonomic ganglia. Moreover, once the DRG precursors aggregate in their final positions there are still a number of fate choices to be made. The mature DRG is composed of many neurons with different morphologies and distinct biochemical properties as well as glial cells that support these neurons.2