Achieving brain clearance and preventing neurodegenerative diseases-A glymphatic perspective.
Achieving brain clearance and preventing neurodegenerative diseases-A glymphatic perspective.
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实现脑清除和预防神经退行性疾病-胶质淋巴的观点。
DOI：
10.1177/0271678x20982388
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Lundgaard I
中科院分区：
文献类型：
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作者：
Kylkilahti TM;Berends E;Ramos M;Shanbhag NC;Töger J;Markenroth Bloch K;Lundgaard I
神经退行性疾病是社会日益增长的负担，许多是散发性的，这意味着环境，饮食和生活方式起着重要作用。脑脊液（CSF）介导的脑废物通过血管周围通路（称为胶质淋巴系统）的清除正在受到越来越多的关注，因为它提供了了解神经退行性疾病的未探索的观点。胶质淋巴系统参与从大脑中清除代谢副产物，如淀粉样蛋白-β，并且其功能被认为可以降低发展一些最常见的神经退行性疾病的风险。在这里，我们提出的磁共振成像（MRI）数据的心脏周期的控制CSF流量在人类证实了从动物研究的结果。我们还回顾了睡眠，饮食，血管健康对胶质淋巴清除的重要性，并发现这些因素也是大脑寿命的已知因素。
Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity.