Fundus Autofluorescence and Photoreceptor Bleaching in Multiple Evanescent White Dot Syndrome
Fundus Autofluorescence and Photoreceptor Bleaching in Multiple Evanescent White Dot Syndrome
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DOI：
10.3928/23258160-20131105-08
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发表时间：
2013-11-01
影响因子：
1
通讯作者：
Sarraf, David
中科院分区：
文献类型：
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作者：
Joseph, Anthony;Rahimy, Ehsan;Sarraf, David
作者报告了3例具有特征性眼底自发荧光（FAF）表现的多发性渐逝性白色斑点综合征（MEWDS），其中1例患者眼底镜检查时无任何可见白色斑点，另1例患者眼底镜检查时有更多的自发荧光病变。此外，研究结果支持MEWDS中超自发荧光病变的替代机制，即感光细胞损失导致正常基础视网膜色素上皮自发荧光的暴露。这一假设在两个案例中得到证实，光学相干断层扫描显示清晰的椭圆形区域衰减与登记的超自发荧光病变。在两种情况下，通过在同一会话中捕获的连续FAF图像中的感光体漂白，导致特征点的自发荧光强度降低，进一步支持了这一点。
The authors present three cases of multiple evanescent white dot syndrome (MEWDS) with characteristic fundus autofluorescence (FAF) findings, including one patient without any visible white dots on funduscopic examination and another with many more hyperautofluorescent lesions than seen ophthalmoscopically. Additionally, the findings support an alternative mechanism for the hyperautofluorescent lesions in MEWDS, whereby photoreceptor loss causes unmasking of normal underlying retinal pigment epithelium autofluorescence. This hypothesis is demonstrated in two cases by optical coherence tomography showing clear ellipsoid zone attenuation with registration to hyperautofluorescent lesions. It is further supported in two cases by photoreceptor bleaching in successive FAF images captured in the same session leading to diminished autofluorescence intensity of the characteristic dots.