A reduced-glycemic load diet in the treatment of adolescent obesity
A reduced-glycemic load diet in the treatment of adolescent obesity
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DOI：
10.1001/archpedi.157.8.773
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发表时间：
2003-08-01
影响因子：
--
通讯作者：
Ludwig, DS
中科院分区：
文献类型：
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作者：
Ebbeling, CB;Leidig, MM;Ludwig, DS
背景：青春期后肥胖儿童2型糖尿病的发病率显著增加。然而，膳食成分对青少年体重和糖尿病危险因素的影响尚未得到研究。目的：比较随意、降低血糖负荷（GL）饮食与能量限制、降低脂肪饮食对肥胖青少年的影响。设计：随机对照试验，包括6个月的干预和6个月的随访。主要结局指标：在第0、6和12个月测量身体组成（体重指数[BMI；以体重（公斤）除以身高（米）的平方计算]和脂肪量）和胰岛素抵抗（体内平衡模型评估）。7天的饮食日记被用作过程测量。研究对象：16名13至21岁的肥胖青少年。干预措施：实验（降低gl）治疗强调选择低血糖指数至中等的食物，其中45%至50%的能量来自碳水化合物，30%至35%来自脂肪。相比之下，传统的（减脂）治疗强调选择低脂产品，55%至60%的能量来自碳水化合物，25%至30%来自脂肪。结果：14名受试者完成研究（每组7名）。试验组GL显著降低，常规组饲粮脂肪显著降低(P
Background: The incidence of type 2 diabetes increases markedly for obese children after puberty. However, the effect of dietary composition on body weight and diabetes risk factors has not been studied in adolescents.Objective: To compare the effects of an ad libitum, reduced-glycemic load (GL) diet with those of an energy-restricted, reduced-fat diet in obese adolescents.Design: Randomized control trial consisting of a 6-month intervention and a 6-month follow-up.Main Outcome Measures: Body composition (body mass index [BMI; calculated as weight in kilograms divided by the square of height in meters] and fat mass) and insulin resistance (homeostasis model assessment) were measured at 0, 6, and 12 months. Seven-day food diaries were used as a process measure.Subjects: Sixteen obese adolescents aged 13 to 21 years.Intervention: Experimental (reduced-GL) treatment emphasized selection of foods characterized by a low to moderate glycemic index, with 45% to 50% of energy from carbohydrates and 30% to 35% from fat. in contrast, conventional (reduced-fat) treatment emphasized selection of low-fat products, with 55% to 60% of energy from carbohydrates and 25% to 30% from fat.Results: Fourteen subjects completed the study (7 per group). The GL decreased significantly in the experimental group, and dietary fat decreased significantly in the conventional group (P