Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture.
Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture.
复制标题
DOI：
10.1016/j.tibtech.2018.01.001
复制
发表时间：
2018-10
影响因子：
17.3
通讯作者：
M. C. Nweke;A. Rathore;D. Bracewell
中科院分区：
文献类型：
--
作者：
M. C. Nweke;A. Rathore;D. Bracewell
对导致色谱柱老化的事件了解不足，难以监测色谱柱寿命。由于该领域缺乏既定程序，因此很难建立行业标准。因此，重要的是要了解树脂老化的机制和技术，以监测色谱柱在操作过程中的老化。
Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.