Daytime napping and risk of liver cancer: A large population-based prospective cohort study
Daytime napping and risk of liver cancer: A large population-based prospective cohort study
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DOI：
10.1016/j.aohep.2022.100877
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发表时间：
2022-12-05
影响因子：
3.8
通讯作者：
Iso，Hiroyasu
中科院分区：
文献类型：
--
作者：
Arafa，Ahmed;Eshak，Ehab S.;Iso，Hiroyasu
肝癌是日本和世界范围内发病率和死亡率的主要原因。白天小睡是一种常见的行为，特别是在老年人中，在以前的研究中与不利的健康状况有关。在此，我们调查了白天小睡和肝癌risk.Materials和MethodsIn这个前瞻性队列研究，数据从51,185名参与者年龄在40-79岁，并在日本协作队列研究（JACC研究）进行了分析。肝癌的发病病例是通过癌症登记、医院记录和死亡证明来诊断的。日间小睡使用JACC基线自填问卷进行评估。我们使用的考克斯回归计算风险比（HR）和95%的置信区间（CI）的参与者中的40年代，50年代，60年代和70年代谁报告白天小睡与他们的同行相比，谁没有。ResultsWithin 669,734人年的随访，341名参与者患肝癌。在调整性别后的60多岁和70多岁的参与者中，白天小睡与肝癌的高风险相关：HR（95% CI）1.88（1.35-2.61）和1.96（1.18-3.26），生活方式和病史：1.76（1.27-2.47）和1.82（1.07-3.09）;肝病史分别为1.66（1.18-2.34）和1.72（1.01-2.94）。在40和50岁年龄组的参与者中没有发现任何相关性。ConclusionsDaytime napping与老年人患肝癌的风险较高相关。
Introduction and ObjectivesLiver cancer is a major cause of morbidity and mortality in Japan and worldwide. Daytime napping is a common behavior, especially among older adults, that was related in previous research to unfavorable health conditions. Herein, we investigated the association between daytime napping and liver cancer risk.Materials and MethodsIn this prospective cohort study, data from 51,185 participants aged 40–79 years and registered in the Japan Collaborative Cohort Study (JACC Study) were analyzed. Incident cases of liver cancer were diagnosed using cancer registries, hospital records, and death certificates. Daytime napping was assessed using the JACC baseline self-administered questionnaire. We used the Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident liver cancer among participants in the age categories of the 40s, 50s, 60s, and 70s who reported daytime napping compared with their counterparts who did not.ResultsWithin 669,734 person-years of follow-up, 341 participants developed liver cancer. Daytime napping was associated with a higher risk of liver cancer among participants who were in their 60s and 70s of age after adjusting for sex: HRs (95% CIs) 1.88 (1.35–2.61) and 1.96 (1.18–3.26), lifestyle and medical history: 1.76 (1.27–2.47) and 1.82 (1.07–3.09), and history of liver diseases: 1.66 (1.18–2.34) and 1.72 (1.01–2.94), respectively. No associations were detected among participants from the 40s and 50s age groups.ConclusionsDaytime napping was associated with a higher risk of liver cancer among older adults.