Causal evidence that intrinsic beta-frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS.
Causal evidence that intrinsic beta-frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS.
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DOI：
10.1016/j.neuroimage.2015.11.020
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发表时间：
2016-02-01
期刊：
影响因子：
5.7
通讯作者：
Bestmann S
中科院分区：
文献类型：
--
作者：
Romei V;Bauer M;Brooks JL;Economides M;Penny W;Thut G;Driver J;Bestmann S
相关的证据为脑振荡支持神经计算的观点提供了支持。最近的工作，在人类中使用节律刺激技术提供了因果关系的证据，但这些外部信号与内在节律的相互作用仍然不清楚。在这里，我们表明，感觉运动皮层遵循外部施加的节奏TMS（rTMS）刺激的β带，但引发的反应是最强的内在的个人β峰频率。虽然这些夹带效应的持续时间很短，但即使是亚阈值rTMS脉冲也会通过网络传播，并引起显著的皮质-脊髓耦合，特别是当以单独的β频率刺激时。我们的研究结果表明，外部强制的节奏与内在的脑节律相互作用，使个人的峰值频率决定的rTMS的效果。在共振频率下观察到的下游脊髓效应为脑节律对信号传播的因果作用提供了证据。阈下节律性经颅磁刺激（TMS）在β-频率下在休息时会影响运动皮层。TMS在运动皮层中的夹带在个体β频率处最大。阈下TMS在该共振频率下诱导皮质-脊髓耦合。皮质脊髓网络就像一个β带通滤波器，即使在低肌肉张力。
Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta peak frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency. Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation. Subthreshold rhythmic TMS at beta-frequency entrains the motor cortex at rest. TMS entrainment in the motor cortex is maximal at the individual beta-frequency. Subthreshold TMS induces cortico-spinal coupling at this resonance frequency. Cortico-spinal network acts like a beta-band-pass filter even at low muscle tone.