Adaptive electric field control of epileptic seizures
Adaptive electric field control of epileptic seizures
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DOI：
10.1523/jneurosci.21-02-00590.2001
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发表时间：
2001-01-15
影响因子：
5.3
通讯作者：
Schiff, SJ
中科院分区：
文献类型：
--
作者：
Gluckman, BJ;Nguyen, H;Schiff, SJ
我们描述了一种新的方法，自适应地控制癫痫样事件在海马脑片使用电场。通过差分细胞外记录技术在场应用期间连续记录细胞外神经元活动，并且使用计算机控制的比例反馈算法连续更新所施加的电场强度。当与负反馈一起使用时，这种方法似乎能够持续改善该制剂中的癫痫发作事件。通过正反馈使用相反极性的场可以诱发或增强癫痫发作。在负反馈模式下，这些发现可能为癫痫控制提供一种新的技术。在正反馈模式下，自适应施加的电场可以提供比以前可能的更生理的神经调制手段用于假体目的。
We describe a novel method of adaptively controlling epileptic seizure-like events in hippocampal brain slices using electric fields. Extracellular neuronal activity is continuously recorded during field application through differential extracellular recording techniques, and the applied electric field strength is continuously updated using a computer-controlled proportional feedback algorithm. This approach appears capable of sustained amelioration of seizure events in this preparation when used with negative feedback. Seizures can be induced or enhanced by using fields of opposite polarity through positive feedback. In negative feedback mode, such findings may offer a novel technology for seizure control. In positive feedback mode, adaptively applied electric fields may offer a more physiological means of neural modulation for prosthetic purposes than previously possible.