The relationship among brain, spinal cord and anesthetic requirements
The relationship among brain, spinal cord and anesthetic requirements
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DOI：
10.1016/s0306-9877(97)90028-1
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发表时间：
1997-01-01
影响因子：
4.7
通讯作者：
Antognini, JF
中科院分区：
文献类型：
--
作者：
Antognini, JF
脊髓是麻醉剂抑制对伤害性刺激的反应的运动的关键部位。对脊髓的兴奋和抑制影响的平衡可能决定运动反应的程度，因此对麻醉需求很重要。当挥发性麻醉剂异氟烷被选择性地输送到原位山羊脑（躯干中的浓度较低）时，麻醉剂需求急剧增加，但当低浓度异氟烷被输送到脑时，躯干中的麻醉剂需求降低。当高临床浓度的异氟烷（6-10%）被输送到大脑而不是躯干时，会发生自发运动。这些结果最好解释为麻醉剂对脊髓神经元和脑神经元（中脑网状结构）的不同作用。在异氟烷向大脑和脊髓的差异输送过程中，检查背角和中脑网状结构中的神经元以及肌电图，将检验这一假设。
The spinal cord is a crucial site wherein anesthetics suppress movement in response to noxious stimuli. The balance of excitatory and inhibitory influences on the spinal cord likely determines the extent of motor response, and is thus important to anesthetic requirements. When the volatile anesthetic isoflurane is selectively delivered to the in situ goat brain (with low concentrations in the torso), anesthetic requirements increase dramatically, but when low isoflurane concentrations are delivered to the brain, anesthetic requirements decrease in the torso. When high, supraclinical concentrations of isoflurane (6-10%) are delivered to the brain and not to the torso, spontaneous movement occurs. These results are best explained by a differential effect of anesthetics on spinal cord neurons and cerebral neurons (midbrain reticular formation). Examination of neurons in the dorsal horn and midbrain reticular formation, and the electromyogram, during differential delivery of isoflurane to brain and spinal cord, will test this hypothesis.