Regional magnetic resonance spectroscopy of the brain in autistic individuals
Regional magnetic resonance spectroscopy of the brain in autistic individuals
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DOI：
10.1007/s002340000520
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发表时间：
2001-06-01
期刊：
影响因子：
2.8
通讯作者：
Mori, K
中科院分区：
文献类型：
--
作者：
Hisaoka, S;Harada, M;Mori, K
我们用多元协方差分析研究了自闭症患者和正常对照组代谢物浓度随脑区和年龄的变化。我们检查了55名自闭症患者(2-21岁，男47名，女8名)和51名正常儿童(3个月-15岁，男26名，女25名)。在两侧的额叶、顶叶和颞区、脑干和扣带回放置了单个感兴趣的体积。用水参比法测定各代谢物的浓度。自闭症患者颞区(Brodmann‘s区41和42)的N-乙酰天冬氨酸浓度显著低于对照组(P<；0.05)，而其他区域的浓度与对照组无显著差异。这提示自闭症患者Brodmann区41和42区神经元密度低或功能障碍，这可能与自闭症患者感觉语言中枢(WerNicke区)的紊乱有关。
We studied the variations in the concentration of metabolites with brain region and age in autistic individuals and normal controls using multiple analysis of covariance. We examined 55 autistic individuals (2-21 years old, 47 male and eight female) and 51 normal children (3 months-15 years old, 26 boys and 25 girls). Single volumes of interest were placed in the frontal, parietal and temporal region on both sides, the brain stem and cingulate gyrus. The concentration of each metabolite was quantified by the water reference method. The concentration of N-acetylaspartate in the temporal regions (Brodmann's areas 41 and 42) in the autistic individuals were significantly lower than those in the controls (P < 0.05), but concentrations in other regions were not significantly different between the autistic individuals and controls. This suggests low density or dysfunction of neurones in Brodmann's areas 41 and 42 in autistic individual, which might be related to the disturbances of the sensory speech centre (Wernicke's area) in autism.