The role of the intrinsic apoptosis pathway in platelet life and death
The role of the intrinsic apoptosis pathway in platelet life and death
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DOI：
10.1111/j.1538-7836.2009.03366.x
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发表时间：
2009-07-01
影响因子：
10.4
通讯作者：
Kile, B. T.
中科院分区：
文献类型：
--
作者：
Kile, B. T.
近年来，越来越明显的是，血小板的产生及其随后在循环中的寿命至少部分地由凋亡机制调节。也有证据表明，在血小板功能反应的调节中涉及凋亡机制。本文综述了由Bcl-2蛋白家族调控的内在凋亡途径在血小板生物学中的作用。
In recent years, it has become increasingly apparent that the production of platelets and their subsequent life span in the circulation are regulated, at least in part, by apoptotic mechanisms. There is also evidence implicating the apoptotic machinery in the regulation of platelet functional responses. This review examines the role of the intrinsic apoptosis pathway, regulated by the Bcl-2 family of proteins, in platelet biology.