The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome.
The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome.
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DOI：
10.3233/jad-170920
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
De Deyn PP
中科院分区：
文献类型：
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作者：
Dekker AD;Sacco S;Carfi A;Benejam B;Vermeiren Y;Beugelsdijk G;Schippers M;Hassefras L;Eleveld J;Grefelman S;Fopma R;Bomer-Veenboer M;Boti M;Oosterling GDE;Scholten E;Tollenaere M;Checkley L;Strydom A;Van Goethem G;Onder G;Blesa R;Zu Eulenburg C;Coppus AMW;Rebillat AS;Fortea J;De Deyn PP
唐氏综合症（DS）患者易患阿尔茨海默病（AD）。痴呆的行为和心理症状（BPSD）是核心特征，但尚未在DS中进行全面评估。在一项欧洲多学科研究中，开发了新的唐氏综合征痴呆症行为和心理症状量表（BPSD-DS），以确定行为变化的频率和严重程度，并考虑到终身特征行为。在12个临床定义的部分中评估了83个行为项目。主要目的是确定与痴呆状态相关的变化项目，从而可以区分诊断组。结构化访谈进行了知情人DS无痴呆症（DS，n = 149），可疑的痴呆症（DS+Q，n = 65），诊断为痴呆症（DS+AD，n = 67）。 第一探索性数据表明有前途的评分者，重测，内部一致性的可靠性措施。关于项目相关性，组间比较显示焦虑、睡眠障碍、激动和刻板行为、攻击、冷漠、抑郁症状和饮食行为项目的频率和严重程度明显增加。呈现增加的个体比例在DS+AD中最高，在DS+Q中居中，在DS中最低。有趣的是，在DS+Q个体中，相当大比例的人已经表现出焦虑、睡眠障碍、冷漠和抑郁症状的增加，这表明这些变化发生在AD病程的早期。未来的工作应在现有研究结果和临床经验的基础上优化量表，并进一步研究其适用性、信度和效度。未来在日常护理中应用该量表可能有助于护理人员了解变化，并有助于及时干预和适应护理。
People with Down syndrome (DS) are prone to develop Alzheimer’s disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated. The central aim was to identify items that change in relation to the dementia status, and thus may differentiate between diagnostic groups. Structured interviews were conducted with informants of persons with DS without dementia (DS, n = 149), with questionable dementia (DS+Q, n = 65), and with diagnosed dementia (DS+AD, n = 67). First exploratory data suggest promising interrater, test-retest, and internal consistency reliability measures. Concerning item relevance, group comparisons revealed pronounced increases in frequency and severity in items of anxiety, sleep disturbances, agitation & stereotypical behavior, aggression, apathy, depressive symptoms, and eating/drinking behavior. The proportion of individuals presenting an increase was highest in DS+AD, intermediate in DS+Q, and lowest in DS. Interestingly, among DS+Q individuals, a substantial proportion already presented increased anxiety, sleep disturbances, apathy, and depressive symptoms, suggesting that these changes occur early in the course of AD. Future efforts should optimize the scale based on current results and clinical experiences, and further study applicability, reliability, and validity. Future application of the scale in daily care may aid caregivers to understand changes, and contribute to timely interventions and adaptation of caregiving.