Water homeostasis in the brain: Basic concepts
Water homeostasis in the brain: Basic concepts
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DOI：
10.1016/j.neuroscience.2004.07.033
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
Kimelberg, HK
中科院分区：
文献类型：
--
作者：
Kimelberg, HK
哺乳动物CNS通过紧密连接与血液分离，统称为血脑屏障（BBB）。这使得溶剂和水进出CNS的运动具有独特的特征。提出了渗透梯度驱动的水分通量基本方程。然后描述BBB的解剖学和用于脑脊液产生、细胞外液产生和细胞间水和溶质运输的运输过程的生理学。定量分析的需要水通道蛋白为基础的水运动，伴随着已知的CSF生产率。最后，在中枢神经系统中的细胞和血管源性水肿，特别是在水通道蛋白的机制和作用进行了说明。(C)2004年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The mammalian CNS is separated from the blood by tight junctions, collectively termed the blood-brain barrier (BBB). This imposes unique features of solvent and water movement into and out of the CNS. The basic equations for water fluxes driven by osmotic gradients are presented. The anatomy of the BBB and the physiology of the transport processes for cerebrospinal fluid production, extracellular fluid production and intercellular water and solute transport are then described. A quantitative analysis of the need for aquaporin-based water movements to accompany the known rates of CSF production is also presented. Finally, the mechanisms and roles of cellular and vasogenic edema in the CNS, especially in relation to aquaporins, are described. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.