Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident
Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident
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DOI：
10.1038/sj.bjc.6605967
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发表时间：
2011-01-04
影响因子：
8.8
通讯作者：
Masyakin, V. B.
中科院分区：
文献类型：
--
作者：
Zablotska, L. B.;Ron, E.;Masyakin, V. B.
背景：之前的研究表明，接触切尔诺贝利（Chernobyl）事故后释放的放射性碘的儿童和青少年患甲状腺癌的风险增加，但筛查、碘缺乏、暴露年龄和其他因素对剂量反应的影响知之甚少。 方法：我们对白俄罗斯 11 970 名在事故发生时年龄为 18 岁或以下且估计 I-131 的个体进行了筛查 甲状腺剂量基于个体甲状腺活性测量和问卷剂量测定数据。使用线性和线性指数函数对每格雷的超额比值比 (EOR/Gy) 进行建模。 结果：对于甲状腺剂量
BACKGROUND: Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood.METHODS: We screened 11 970 individuals in Belarus aged 18 years or younger at the time of the accident who had estimated I-131 thyroid doses based on individual thyroid activity measurements and dosimetric data from questionnaires. The excess odds ratio per gray (EOR/Gy) was modelled using linear and linear-exponential functions.RESULTS: For thyroid doses