On the structure of biocompatible, thermoresponsive poly(ethylene glycol) microgels
On the structure of biocompatible, thermoresponsive poly(ethylene glycol) microgels
复制标题
DOI：
10.1016/j.polymer.2014.10.069
复制
发表时间：
2014-12-15
期刊：
影响因子：
4.6
通讯作者：
Wellert, Stefan
中科院分区：
文献类型：
--
作者：
Gawlitza, Kornelia;Radulescu, Aurel;Wellert, Stefan
本研究的目的是微凝胶颗粒的制备和表征，与其他微凝胶相反，具有温度响应性和生物相容性。因此，通过沉淀聚合法合成了单分散的p-MeO（2）MA-co-OEGMA微凝胶颗粒。研究了聚乙二醇（PEG）基微凝胶粒子的溶胀/去溶胀行为和结构。动态光散射（DLS）和小角中子散射（SANS）的组合使用。通过改变共聚单体的量，可以调节粒径和体积相变温度（VPTT）。SANS测量表明在溶胀状态下的PEG微凝胶的非均匀结构。在高于VPTT的温度下，观察到紧凑的结构。共聚单体含量的增加导致在溶胀状态下的密集堆积的核和模糊的壳。此外，在体积相变（VPT）周围的温度范围内观察到聚合物网络内的纳米畴。由于在溶胀状态下的这种异质结构，观察到网络波动的两个相关长度。(C)2014爱思唯尔有限公司版权所有。
The aim of the present study is the preparation and characterization of microgel particles which are, contrary to other microgels, thermoresponsive as well as biocompatible. Hence, monodisperse p-MeO(2)MA-co-OEGMA microgel particles were synthesized by precipitation polymerization. Swelling/deswelling behavior and the structure of poly(ethylene glycol) (PEG) based microgel particles were investigated. A combination of dynamic light scattering (DLS) and small angle neutron scattering (SANS) was used. Particle size and the volume phase transition temperature (VPTT) are adjustable by changing the amount of comonomer. SANS measurements indicate an inhomogeneous structure of the PEG microgels in the swollen state. At temperatures above the VPTT a compact structure was observed. An increase of the comonomer content leads to a densely packed core and a fuzzy shell in the swollen state. Additionally, nanodomains inside the polymer network were observed in the temperature range around the volume phase transition (VPT). Due to this heterogeneous structure in the swollen state two correlation lengths of the network fluctuations were observed. (C) 2014 Elsevier Ltd. All rights reserved.