Increased perceived stress is associated with blunted hedonic capacity: Potential implications for depression research
Increased perceived stress is associated with blunted hedonic capacity: Potential implications for depression research
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DOI：
10.1016/j.brat.2007.07.013
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发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Jahn, Allison L.
中科院分区：
文献类型：
--
作者：
Pizzagalli, Diego A.;Bogdan, Ryan;Jahn, Allison L.
临床前研究表明，应激通过损害享乐能力而产生抑郁效应，然而，在人类中，应激与抑郁的确切机制很大程度上是未知的。作为更好地了解压力和快感缺乏症之间的联系的第一步，本研究在两个独立的样本中测试了报告压力增加的个人是否表现出享乐能力下降。感知压力量表(PSS)测量了参与者对他们的日常生活评价为不可预测、无法控制和不堪重负的程度。使用基于不同强化计划的信号检测任务来客观地评估享乐能力。降低的奖赏反应性(即，参与者将行为作为奖赏的函数来调节的倾向)被用作享乐能力的可操作测量。在研究1(n=88)和研究2(n=80)中，PSS得分高的参与者表现出迟钝的奖励反应和报告的非快感症状增加。此外，PSS分数预测，即使在控制了一般的痛苦和焦虑症状后，奖励反应性也会降低。这些发现与强调压力和快感缺乏之间的联系的临床前数据是一致的，并为将压力与抑郁联系起来的潜在机制提供了有希望的见解。(C)2007爱思唯尔有限公司。保留所有权利。
Preclinical Studies suggest that stress exerts depressogenic effects by impairing hedonic capacity, in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards better understanding the association between stress and anhedonia, the present study tested, in two independent samples, whether individuals reporting elevated stress exhibit decreased hedonic capacity. The Perceived Stress Scale (PSS) measured the decree to which participants appraised their daily life as unpredictable, uncontrollable, and overwhelming. Hedonic capacity was objectively assessed using a signal-detection task based on a differential reinforcement schedule. Decreased reward responsiveness (i.e., the participants propensity to modulate behavior as a function of reward) was used as an operational measure of hedonic capacity. In both Study 1 (n = 88) and Study 2 (n = 80), participants with high PSS scores displayed blunted reward responsiveness and reported elevated anhedonic symptoms. Additionally, PSS scores predicted reduced reward responsiveness even after controlling for general distress and anxiety symptoms. These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression. (C) 2007 Elsevier Ltd. All rights reserved.