A Forster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
A Forster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
复制标题
用于生物成像的具有 H2S 激活第二近红外发射功能的 Förster 共振能量转移可切换荧光探针
DOI：
10.3389/fchem.2019.00778
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发表时间：
2019-11-25
影响因子：
5.5
通讯作者：
Zhao, Chunchang
中科院分区：
文献类型：
--
作者：
Wang, Rongchen;Gao, Wei;Zhao, Chunchang
实时、准确地检测内源性硫化氢具有重要的生物医学意义。在这里，用于比率检测H2S的基于FRET的荧光探针被设计为包括作为能量供体的AIE发光体TPE和作为能量受体和H2S响应位点的单氯化BODIPY染料。这种设计的探针显示出H2S依赖性比率和点亮NIR-II发射，使得能够对富含H2S的癌细胞进行准确成像并以高分辨率识别富含H2S的肿瘤。
Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H2S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H2S-responsive site. Such a designed probe showed H2S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H2S-rich cancer cells and identification of H2S-rich tumors with high resolution.