Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients.
Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients.
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CYP3A5基因多态性对成人肝移植患者他克莫司浓度/剂量比的影响。
DOI：
10.4238/2015.november.25.3
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
S. Lu
中科院分区：
文献类型：
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作者：
Lefeng Wang;Lianhe Liu;Tong Wh;Meng;S. Lu
我们研究了供受者细胞色素P450 3A5基因对中国肝移植患者他克莫司浓度-剂量比(C/D)的影响。51名接受他克莫司治疗的成人肝移植患者被纳入本研究。在移植时检测供受者的细胞色素P3A5基因多态性，并根据每个患者的遗传构成开始他克莫司免疫抑制治疗。分析术后3个月他克莫司C/D比值与细胞色素P3A5基因的关系。采用逐步回归模型分析他克莫司在肝移植患者中的C/D与基因型、病程、年龄、肝脏重量的关系。肝移植术后3个月，供、受者的C/D值均受CYP3A5基因的影响。肝脏中携带CYP3A5*1等位基因或携带CYP3A5*1等位基因的患者他克莫司的C/D值明显低于肝脏中携带CYP3A5*3/*3等位基因的患者(P<0.01)。供者和患者的CYP3A5*1基因均可导致成人肝移植患者他克莫司C/D的个体间差异。
We examined the influence of the cytochrome P450 3A5 (CYP3A5) genes in both donors and recipients on the concentration-dosage ratio (C/D) of tacrolimus in Chinese liver transplant patients. Fifty-one adult liver transplant patients who received tacrolimus were included in this study. The CYP3A5 polymorphism in donors and recipients was determined at the time of transplantation, and tacrolimus-based immunosuppressive therapy was started based on each patient's genetic constitution. The relationship between the C/D of tacrolimus for 3 months after surgery and the CYP3A5 genotype was analyzed. A stepwise regression model was used to analyze the relationship between C/D of tacrolimus and genotype, time course, age, and liver weight in liver transplant patients. Three months after liver transplantation, C/D was both affected by the CYP3A5 genotype of both the donors and the recipients. The C/D of tacrolimus in patients with the CYP3A5*1 allele or carrying CYP3A5*1 allele in the liver was lower than that in CYP3A5*3/*3 patients with the CYP3A5*3/*3 genotype in the liver (P < 0.01). The CYP3A5*1 genotype in donors as well as in patients both contributes to interindividual variation in the C/D of tacrolimus in adult liver transplantation.
DOI：
10.1097/01.fpc.0000114747.08559.49
发表时间：
2004-07-01
期刊：
PHARMACOGENETICS
影响因子：
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作者：
Goto, M;Masuda, S;Inui, K
通讯作者：
Inui, K