Response of human osteoblasts exposed to wear particles generated at the interface of total hip stems and bone cement
Response of human osteoblasts exposed to wear particles generated at the interface of total hip stems and bone cement
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DOI：
10.1002/jbm.a.31996
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发表时间：
2009-05-01
影响因子：
4.9
通讯作者：
Bader, Rainer
中科院分区：
文献类型：
--
作者：
Lenz, Robert;Mittelmeier, Wolfram;Bader, Rainer
磨损颗粒是引起全髋关节置换术后无菌性松动的主要原因。磨粒磨损发生在关节面，或者是股骨柄和骨水泥之间界面微动的结果。描述了磨损颗粒对骨溶解、骨量重塑和成骨细胞功能的直接影响。本研究检查了暴露于不同磨损颗粒的人成骨细胞的反应，这些磨损颗粒是在股骨柄和标准骨水泥之间的界面处提供振荡微动的测试装置中产生的。通过量化磨屑的粒度分布和金属含量来表征释放的颗粒。将人成骨细胞与从具有不同材料组成（Ti-6Al-7 Nb和Co-28 Cr-6 Mo）的髋关节柄获得的颗粒以及与含有氧化锆颗粒的标准骨水泥（Palacos（R）R）组合的粗糙和光滑表面修整物一起孵育。商业纯钛颗粒（cp-Ti）和颗粒状氧化锆（ZrO 2）用于比较分析。结果显示，显著（p
Aseptic loosening of total hip replacement is mainly caused by wear particles. Abrasive wear occurs at articulating surfaces or as a consequence of micro-motions at the interface between femoral stem and bone cement. Direct impact of wear particles on osteolysis, the remodeling of the bone stock and a directly affected function of osteoblasts was described. The present study examined the response of human osteoblasts exposed to different wear particles, which were generated in a test device providing oscillating micro-motions at the interface between femoral stem and standard bone cement. Characterization of released particles was performed by quantifying the size distribution and the metal content of the wear debris. Human osteoblasts were incubated with particles obtained from hip stems with different material compositions (Ti-6Al-7Nb and Co-28Cr-6Mo) and rough and smooth surface finishings combined with standard bone cement (Palacos (R) R) containing zirconium oxide particles. Commercially pure titanium particles (cp-Ti) and particulate zirconium oxide (ZrO2) were used for comparative analyses. The results revealed significant (p