Nanosensor Design Packages: A Smart and Compact Development for Metal Ions Sensing Responses†
Nanosensor Design Packages: A Smart and Compact Development for Metal Ions Sensing Responses†
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DOI：
10.1002/adfm.200700447
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发表时间：
2007-12
影响因子：
19
通讯作者：
S. El‐Safty;D. Prabhakaran;A. Ismail;H. Matsunaga;F. Mizukami
中科院分区：
文献类型：
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作者：
S. El‐Safty;D. Prabhakaran;A. Ismail;H. Matsunaga;F. Mizukami
近年来，随着介观结构材料和纳米技术的发展，光学传感器和生物传感器的设计以及高灵敏度固体传感器的开发都出现了新的方法。在这里，通过固定化市售的a，B，c，d-四甲基偶氮苯，成功地开发了用于肉眼检测有毒金属离子的高灵敏度、低成本、简单的纳米传感器设计。（1-甲基吡啶鎓-4-基）卟啉对甲苯磺酸盐（TMPyP）和二苯基卡巴肼（DPC），并将4-正十二烷基-6-（2-噻唑偶氮）间苯二酚（DTAR）和4-正十二烷基-6-（2-吡啶偶氮）苯酚（DPAP）发色团分子化学合成为球形纳米尺寸的空腔和表面。一个合理的策略是至关重要的，以开发光学纳米传感器，可用于控制准确的识别和信号能力的分析物物种的离子传感器的目的。这是第一次报道的证据的显着的关键因素的发展受体作为“指示染料”和表面限制材料作为“载体”，以扩大适用性的光学化学传感器的痕量水平的有毒分析物的选择性歧视。在这里提出的所有纳米传感器的设计技术，固定化的疏水性的“中性”和亲水性的“带电”的生色团与固有的流动性，作为一个非常强大的构建序列的结果，在纳米级结构的密集模式，是一个关键，以提高光学纳米传感器的传感功能。这些纳米传感器的设计可以被用作笼式探针水槽与可靠的控制，第一次，在比色识别镉离子的浓度范围为10 - 9至10 - 10 M的低水平。建立控制传感条件的优化，以实现增强的信号响应和颜色强度。这些化学纳米传感器是可逆的，并有可能有效地用于现场环境样品的现场分析，从而消除了依赖于仪器的分析的必要性。此外，这些新类别的光学笼传感器表现出信号和识别功能的长期稳定性，通常提供非凡的灵敏度，选择性，可重复使用性，以及对我们环境中各种有害金属离子的快速动力学检测和定量。
With recent advances in mesostructured materials and nanotechnologies, new methods are emerging to design optical sensors and biosensors, and to develop highly sensitive solid sensors. Here, highly sensitive, low cost, simple nanosensor designs for naked-eye detection of toxic metal ions are successfully developed by the immobilization of commercially available a,b,c,d-tetrakis(1-methylpyridinium-4-yl)porphine p-toluenesulfonate (TMPyP) and diphenylcarbazide (DPC), and chemically synthesized 4-n-dodecyl-6-(2-thiazolylazo) resorcinol (DTAR) and 4-n-dodecyl-6-(2-pyridylazo) phenol (DPAP) chromophore molecules into spherical nanosized cavities and surfaces. A rational strategy was crucial to develop optical nanosensors that can be used to control accurate recognition and signaling abilities of analyte species for ion-sensing purposes. This is the first reported evidence of the significant key factors of the development of receptors as ‘indicator dyes’ and surface-confinement materials as ‘carriers’ to broadening the applicability of optical chemical sensors for selective discrimination of trace levels of toxic analytes. In all the nanosensor design techniques presented here, a dense pattern of immobilized hydrophobic ‘neutral’ and hydrophilic ‘charged’ chromophores with intrinsic mobility, as a result of extremely robust constructed sequences on nanoscale structures, is a key to enhancing the sensing functionality of optical nanosensors. These nanosensor designs can be used as cage probe sinks with reliable control, for the first time, over the colorimetric recognition of cadmium ions to low levels of concentration in the range of 10 –9 to 10 –10 M. Optimization of control sensing conditions is established to achieve enhanced signal response and color intensities. These chemical nanosensors are reversible and have the potential to serve effectively in on-site field analysis of environmental samples, which eliminates the necessity for instrument-dependent analysis. Moreover, these new classes of optical cage sensors exhibit long-term stability of signaling and recognition functionalities that in general provide extraordinary sensitivity, selectivity, reusability, and fast kinetic detection and quantification of various deleterious metal ions in our environment.