Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study
Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study
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DOI：
10.1007/s10157-021-02089-6
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发表时间：
2021-06-07
影响因子：
2.3
通讯作者：
Kitazono, Takanari
中科院分区：
文献类型：
--
作者：
Hiyamuta, Hiroto;Yamada, Shunsuke;Kitazono, Takanari
尽管血液透析患者的死亡率仍然极高，但长期死亡原因的详细信息有限。本研究的目的是阐明日本维持性血液透析患者死亡的根本原因。方法这是一项为期10年的多中心观察性研究，在日本对3528例接受维持性血液透析的门诊患者进行了研究。分析临床结局，并将死亡原因分为六大类，包括心血管疾病、感染性疾病、恶性肿瘤、恶病质、创伤/事故和其他疾病，以及更详细的亚类。结果10年随访期间，1748例（49.5%）患者死亡。最常见的死亡原因是心血管疾病（36.1%），其次是传染病（25.8%）和恶性肿瘤（13.5%）。在详细分类中，猝死、肺部感染和肺癌分别是心血管疾病、传染病和恶性肿瘤中最常见的死亡原因。结论：我们的研究确定了日本血液透析患者在10年随访期间死亡原因的详细信息。心血管疾病，尤其是猝死是血液透析患者的显著死亡原因。
Background Although the mortality rate in patients on hemodialysis remains extremely high, detailed information on causes of death over long-term periods is limited. The aim of this study was to clarify the underlying causes of death in patients undergoing maintenance hemodialysis in Japan. Methods This was a 10-year, multicenter, observational study of 3528 outpatients undergoing maintenance hemodialysis in Japan. Clinical outcomes were analyzed and causes of death were classified into six broad categories including cardiovascular diseases, infectious diseases, malignant neoplasms, cachexia, trauma/accidents, and other diseases, and more detailed subcategories. Results During the 10-year follow-up period, 1748 (49.5%) patients died. The most frequent causes of death were cardiovascular diseases (36.1%), followed by infectious diseases (25.8%) and malignant neoplasms (13.5%). In a detailed classification, sudden death, pulmonary infection, and lung cancer were the most common causes of death in cardiovascular diseases, infectious diseases, and malignant neoplasms, respectively. Conclusion Our study determined details on causes of death in Japanese hemodialysis patients during the 10-year follow-up period. Cardiovascular disease, especially sudden death is noticeable cause of death among patients on hemodialysis.